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Title:
ACHYRANTHES BIDENTATA POLYPEPTIDE AND PRODUCTION METHODS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/127130
Kind Code:
A1
Abstract:
Provided are an Achyranthes bidentata polypeptide and production methods and uses thereof. The Achyranthes bidentata polypeptide is prepared by adding ammonium sulfate into Achyranthes bidentata water solution, centrifuging the solution, again adding ammonium sulfate to supernatant, centrifuging the solution to obtain the residue, dialyzing the residue using aqua water, freeze-drying the solution after dialysis and separating the polypeptide using DEAE column. The Achyranthes bidentata polypeptide can promote nerve growth and prevent neurodegenerative disease.

Inventors:
GU XIAOSONG (CN)
DING FEI (CN)
YUAN YING (CN)
YANG YUMIN (CN)
CHENG QIONG (CN)
Application Number:
CN2009/070410
Publication Date:
October 22, 2009
Filing Date:
February 12, 2009
Export Citation:
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Assignee:
UNIV NANTONG (CN)
GU XIAOSONG (CN)
DING FEI (CN)
YUAN YING (CN)
YANG YUMIN (CN)
CHENG QIONG (CN)
International Classes:
C07K2/00; A61K38/02; A61P25/00; A61P25/02; A61P25/28; C07K1/14; C07K1/36
Foreign References:
CN101270147A2008-09-24
CN101011437A2007-08-08
Other References:
SHEN, H. M. ET AL.: "Polypeptides extract of Achyranthes bidentata Blume protects against NMDA-induced apoptosis in rat cultured hippocampal neurons.", CELL BIOLOGY INTERNATIONAL., vol. 32, no. 3, 20 March 2008 (2008-03-20), pages 510
SHEN, H. M. ET AL.: "The protective effects of Achyranthes bidentata polypeptides against NMDA-induced cell apoptosis in cultured hippocampal neurons through differential modulation of NR2A- and NR2B-containing NMDA receptors.", BRAIN RESEARCH BULLETIN., vol. 77, no. 5, 31 August 2008 (2008-08-31), pages 274 - 281
DING, F. ET AL.: "The repair effects of Achyranthes bidentata extract on the crushed common peroneal nerve of rabbits.", FITOTERAPIA, vol. 79, no. 3, 5 December 2007 (2007-12-05), pages 161 - 167
MARCONE, M. F. ET AL.: "Chemical characterization of Achyranthes bidentata seed.", FOOD CHEMISTRY., vol. 81, no. 1, 2003, pages 7 - 12
HE, Y. X.: "The screening and purification of fibrinolytic enzyme extracted from Achyranthes bidentata and Rubia cordifolia.", CHINESE DOCTORAL DISSERTATIONS & MASTER'S THESES FULL-TEXT DATABASE (MASTER) AGRICULTURE SCIENCE AND TECHNOLOGY., 15 December 2006 (2006-12-15), pages D047 - 335
Attorney, Agent or Firm:
NANJING LAW FIRM OF INTELLECTUAL PROPERTY (9F Sci-Tec CenterNo.5 Xin Mofan Road, Gulo, Nanjing Jiangsu 9, CN)
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