Title:
ACID-LABILE AND ENZYMATICALLY DIVISIBLE DYE COMPOUNDS FOR DIAGNOSIS WITH NEAR INFRARED LIGHT AND FOR THERAPY
Document Type and Number:
WIPO Patent Application WO1998047538
Kind Code:
A3
Abstract:
The invention relates to acid-labile and enzymatically divisible compounds for in-vivo and in-vitro diagnosis by means of near infrared radiation (NIR-radiation), the use of said compounds as optic diagnostic and therapeutic agents, and the diagnostic agents containing said compounds.
Inventors:
LICHA KAI (DE)
RIEFKE BJOERN (DE)
SEMMLER WOLFHARD (DE)
WRASIDLO WOLFGANG (DE)
RIEFKE BJOERN (DE)
SEMMLER WOLFHARD (DE)
WRASIDLO WOLFGANG (DE)
Application Number:
PCT/DE1998/001001
Publication Date:
January 21, 1999
Filing Date:
April 02, 1998
Export Citation:
Assignee:
DIAGNOSTIKFORSCHUNG INST (DE)
LICHA KAI (DE)
RIEFKE BJOERN (DE)
SEMMLER WOLFHARD (DE)
WRASIDLO WOLFGANG (DE)
LICHA KAI (DE)
RIEFKE BJOERN (DE)
SEMMLER WOLFHARD (DE)
WRASIDLO WOLFGANG (DE)
International Classes:
A61K41/00; A61K49/00; A61P35/00; C07D209/08; C07D493/10; C07H15/252; C09B23/08; C09B69/10; G01N33/574; G01N33/58; (IPC1-7): A61K49/00
Domestic Patent References:
| WO1996017628A1 | 1996-06-13 | |||
| WO1998022146A2 | 1998-05-28 | |||
| WO1997013490A2 | 1997-04-17 |
Foreign References:
| EP0476408A1 | 1992-03-25 | |||
| EP0175617A2 | 1986-03-26 | |||
| EP0800831A1 | 1997-10-15 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 095, no. 009 31 October 1995 (1995-10-31)
LICHA, KAI ET AL: "Synthesis and characterization of cyanine dye - poly(ethylene glycol) conjugates as contrast agents for in vivo fluorescence imaging", PROC. SPIE-INT. SOC. OPT. ENG., 1998, 3196, 98-102, XP002079471
LICHA, K. ET AL: "Synthesis and characterization of cyanine dyes as contrast agents for near-infrared imaging", PROC. SPIE-INT. SOC. OPT. ENG., 1996, 2927, 192-198, XP002079648
LICHA, KAI ET AL: "Synthesis and characterization of cyanine dye - poly(ethylene glycol) conjugates as contrast agents for in vivo fluorescence imaging", PROC. SPIE-INT. SOC. OPT. ENG., 1998, 3196, 98-102, XP002079471
LICHA, K. ET AL: "Synthesis and characterization of cyanine dyes as contrast agents for near-infrared imaging", PROC. SPIE-INT. SOC. OPT. ENG., 1996, 2927, 192-198, XP002079648
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