Title:
LIPOSOME–NUCLEIC ACID NANO-FUSION FOR QUANTITATIVE DIAGNOSIS OF MULTIPLE RIBONUCLEIC ACID MARKERS, THEORETICAL STABILITY EVALUATION METHOD THEREFOR, APPLICATION THEREOF, AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/155880
Kind Code:
A1
Abstract:
The present invention relates to: a liposome–nucleic acid nano-fusion for the quantitative diagnosis of multiple ribonucleic acid markers, the nano-fusion containing, in a liposome, a silica sphere having bound to the surface thereof a nucleic acid nano-structure having a first nucleic acid structure, which is branched and has a cyclic end, bonded with a second nucleic acid structure, which is branched and has a cyclic end; a theoretical stability evaluation method for the nano-fusion; an imaging system using the nano-fusion in disease diagnosis; and a production method for the nano-fusion. By using the liposome–nucleic acid nano-fusion according to the present invention, an advantage may be achieved whereby the difference in aspects of RNA expression among various cell lines may be quantitatively compared, and the difference among cells in a single cell line may be checked, and thus multiple intracellularly-expressed cancer-specific RNA markers acquired in an actual clinical setting may be diagnosed in real-time, and on the basis thereof, information required for diagnosis and treatment may be easily acquired.
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Inventors:
UM SOONG-HO (KR)
SHIN SEUNG-WON (KR)
SHIN SEUNG-WON (KR)
Application Number:
PCT/KR2018/002064
Publication Date:
August 30, 2018
Filing Date:
February 20, 2018
Export Citation:
Assignee:
RESEARCH & BUSINESS FOUND SUNGKYUNKWAN UNIV (KR)
International Classes:
C12Q1/6818; A61K49/00
Foreign References:
| KR20170017103A | 2017-02-15 | |||
| KR101464100B1 | 2014-11-21 | |||
| KR20160071925A | 2016-06-22 | |||
| US20130171646A1 | 2013-07-04 | |||
| KR20110120749A | 2011-11-04 |
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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