ACID SECRETION INHIBITOR

WIPO Patent Application WO/2007/114338

A1

The object is to provide a compound having an excellent inhibitory effect on acid secretion and showing an anti-ulcer activity or the like. Disclosed is a proton pump inhibitor comprising a compound represented by the formula (I) or a salt thereof or a prodrug of the compoun or the salt: (I) wherein the ring A represents a saturated or unsaturated 5- or 6-membered ring group which, in addition to a carbon atom, may have 1 to 4 heteroatoms each selected a nitrogen atom, an oxygen atom and a sulfur atom as the ring-constituting atoms; the ring-constituting atoms X1 and X2 independently represent a carbon atom or a nitrogen atom; the ring-constituting atom X3 represents a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom; R1 represents an aryl group which may be substituted or a heteroaryl group which may be substituted; R2 represents an alkyl group which may be substituted, an aryl group which may be substituted or a heteroaryl group which may be substituted; and R3 is a substituent on a ring-constituting atom other than X1, X2 and X3 and represents an aminomethyl group which may be substituted by 1 to 2 lower alkyl groups, provided that the ring A may further has a substituent selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group.

HASUOKA ATSUSHI (JP)
TAKAGI TERUFUMI (JP)
KAJINO MASAHIRO (JP)
NISHIDA HARUYUKI (JP)

PCT/JP2007/057102

October 11, 2007

March 30, 2007

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TAKEDA PHARMACEUTICAL (JP)
HASUOKA ATSUSHI (JP)
TAKAGI TERUFUMI (JP)
KAJINO MASAHIRO (JP)
NISHIDA HARUYUKI (JP)

A61K31/40; A61K31/415; A61K31/417; A61K31/4178; A61K31/426; A61K31/4439; A61P1/04; A61P43/00; C07D207/36; C07D231/12; C07D233/64; C07D277/20; C07D277/36; C07D401/12; C07D409/12

WO2004103968A1	2004-12-02
WO1999042463A1	1999-08-26
WO2004103968A1	2004-12-02
WO2004007478A2	2004-01-22

JPH0948778A	1997-02-18
EP0259085A1	1988-03-09
JPH08119936A	1996-05-14
US20020193596A1	2002-12-19
JP2006100651A	2006-04-13

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See also references of EP 2005957A4

TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome,,Chuo-ku,,Osaka-shi, Osaka44, JP)

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