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Title:
ACRYLIC COMPOUND AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/219016
Kind Code:
A1
Abstract:
Provided by the present invention are an acrylic compound and a preparation method therefor and a pharmaceutical composition and application thereof. In particular, the present invention provides a compound of formula I, wherein each group is as defined in the specification. The compound can be used as a CREB/CRTC2 interaction inhibitor for the preparation of a pharmaceutical composition for treating diseases such as diabetes. (I)

Inventors:
LIU HONG (CN)
LIU YI (CN)
LI JIA (CN)
WANG JIANG (CN)
CHEN YAQIONG (CN)
JIANG HAOWEN (CN)
WANG YIBING (CN)
XIA CHUNMEI (CN)
FU YANGJIE (CN)
DONG TIANCHENG (CN)
JIANG HUALIANG (CN)
CHEN KAIXIAN (CN)
Application Number:
PCT/CN2019/086905
Publication Date:
November 21, 2019
Filing Date:
May 14, 2019
Export Citation:
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Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
UNIV FUDAN (CN)
International Classes:
C07D263/26; A61K31/15; A61K31/18; A61K31/194; A61K31/422; A61K31/423; A61K31/426; A61K31/428; A61K31/4965; A61P3/10; C07C15/12; C07C15/14; C07D241/04; C07D263/62; C07D265/30; C07D277/14; C07D277/18; C07D405/10; C07D409/06; C07D417/10
Domestic Patent References:
WO2004050022A22004-06-17
Foreign References:
CN101111475A2008-01-23
CN100430386C2008-11-05
US20120088737A22012-04-12
Other References:
ZHAO LEI ET AL.: "Asymmetric beta -boration of a , beta -unsaturatedN-acyloxazolidinones by [2.2]paracyclophane-based bifunctional catalyst", ORGANIC LETTERS, vol. 14, no. 22, 6 November 2012 (2012-11-06), pages 5780 - 5783, XP055654140, ISSN: 1523-7052
CAI: "Michael Addition Reactions between Chiral Ni(II) Complex of Glycine and 3-(trans-Enoyl)oxazolidin-2-ones. A Case of Electron Do- nor-Acceptor Attractive Interaction-Controlled Face Diastereoselectivity", JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 4, 31 January 2001 (2001-01-31) - 23 February 2001 (2001-02-23), pages 1339 - 1350, XP055654144, ISSN: 0022-3263
MAGRIOTI: "New potent and selective polyfluoroalkyl ketone inhi- bitors of GVIA calcium-independent phospholipase A2", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 18, 16 July 2013 (2013-07-16) - 15 September 2013 (2013-09-15), pages 5823 - 5829, XP028693336, ISSN: 0968-0896
ZHAO DEPENG ET AL.: "Highly Efficient Asymmetric Michael Addition of Diaryl Pho-sphine Oxides to a, beta -Unsaturated N-Acylated Oxazolidin-2-ones", CHEMISTRY - AN ASIAN JOURNAL, vol. 7, no. 5, 13 March 2012 (2012-03-13), pages 881 - 883, XP055654145, ISSN: 1861-4728
CONCELLON JOSE: "An Efficient Catalytic Chromium-Mediated Iodocyclop- ropanation Reaction: Stereoselective Synthesis of Iodocyclopropanecarboxamides", ADVANCED SYNTHESIS & CATALYSIS, vol. 353, no. 1, 30 December 2010 (2010-12-30) - 10 January 2011 (2011-01-10), pages 49 - 52, XP055654147, ISSN: 1615-4150
SOLOSHONOK, VADIM: "Application of modular nucleophilic glycine equivalents for truly practical asymmetric synthesis of beta -substituted pyro- glutamic acids", TETRAHEDRON LETTERS, vol. 46, no. 7, 17 December 2004 (2004-12-17) - 14 February 2005 (2005-02-14), pages 1107 - 1110, XP027862455, ISSN: 0040-4039
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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