Title:
ACTIVATED T CELL- AND/OR B CELL-SELECTIVE CELL DEATH INDUCER OR CELL DEATH PROMOTER COMPRISING AS ACTIVE INGREDIENT 25-HYDROXYCHOLESTEROL OR CHOLESTEROL ANALOGOUS THERETO
Document Type and Number:
WIPO Patent Application WO/2017/209270
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an activated T cell- and/or B cell-selective cell death inducer or cell death promoter that is efficacious for preventing or treating diseases that exhibit excessive or abnormal immune function caused by activated T cells and/or activated B cells. A cell death inducer or cell death promoter selective to activated T cells and/or B cells, said cell death inducer or cell death promoter comprising as an active ingredient 25-hydroxycholesterol or a cholesterol analogous thereto.
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Inventors:
TAKAHASHI HAYATO (JP)
AMAGAI MASAYUKI (JP)
AMAGAI MASAYUKI (JP)
Application Number:
PCT/JP2017/020552
Publication Date:
December 07, 2017
Filing Date:
June 02, 2017
Export Citation:
Assignee:
UNIV KEIO (JP)
International Classes:
A61K31/575; A61P37/02; A61P43/00; G01N33/15; G01N33/50; G01N33/92
Other References:
TAKAHASHI H ET AL.: "242 - Novel immune regulation by CD 4+ T cells via chelesterol 25-hydroxylase pathway", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 136, no. 9, September 2016 (2016-09-01), pages S202, XP055599622
PREISS JC ET AL.: "Regulation of Intestinal Inflammation By Interleukin 27 Through T- Cell Apoptosis", GASTROENTEROLOGY, vol. 132, no. 4, 2007, pages A-399
CHALMIN F ET AL.: "Oxysterols impair type 1 regulatory T- cell differentiation and promote autoimmunity", MULTIPLE SCLEROSIS JOURNAL, vol. 20, 2014, pages 315
JUNG EB ET AL.: "Casein kinase 2 inhibition attenuates cholesterol oxidation product-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8-and bid-dependent pathways", NEUROCHEMISTRY INTERNATIONAL, vol. 65, 2014, pages 30 - 39, XP028605027, DOI: doi:10.1016/j.neuint.2013.12.010
BISCHOFF PL ET AL.: "Apoptosis at the interface of Immunosuppressive and Anticancer Activities: The Examples of Two Classes of Chemical Inducers, Oxysterols and Alkylating Agents", CURRENT MEDICINAL CHEMISTRY, vol. 7, 2000, pages 697 - 713
PREISS JC ET AL.: "Regulation of Intestinal Inflammation By Interleukin 27 Through T- Cell Apoptosis", GASTROENTEROLOGY, vol. 132, no. 4, 2007, pages A-399
CHALMIN F ET AL.: "Oxysterols impair type 1 regulatory T- cell differentiation and promote autoimmunity", MULTIPLE SCLEROSIS JOURNAL, vol. 20, 2014, pages 315
JUNG EB ET AL.: "Casein kinase 2 inhibition attenuates cholesterol oxidation product-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8-and bid-dependent pathways", NEUROCHEMISTRY INTERNATIONAL, vol. 65, 2014, pages 30 - 39, XP028605027, DOI: doi:10.1016/j.neuint.2013.12.010
BISCHOFF PL ET AL.: "Apoptosis at the interface of Immunosuppressive and Anticancer Activities: The Examples of Two Classes of Chemical Inducers, Oxysterols and Alkylating Agents", CURRENT MEDICINAL CHEMISTRY, vol. 7, 2000, pages 697 - 713
Attorney, Agent or Firm:
SAEKI, Takuro et al. (JP)
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