Title:
ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE
Document Type and Number:
WIPO Patent Application WO/2013/192165
Kind Code:
A3
Abstract:
N-substituted sulfonylphenyl-5-nitrofuranyl-2- carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
Inventors:
GOLDEN JENNIFER E (US)
AUBE JEFFREY (US)
FLAHERTY DANIEL P (US)
FRIBLEY ANDREW M (US)
KAUFMAN RANDAL J (US)
CHUNG THOMAS D Y (US)
PINKERTON ANTHONY B (US)
HENDRICK MICHAEL PABLO (US)
AUBE JEFFREY (US)
FLAHERTY DANIEL P (US)
FRIBLEY ANDREW M (US)
KAUFMAN RANDAL J (US)
CHUNG THOMAS D Y (US)
PINKERTON ANTHONY B (US)
HENDRICK MICHAEL PABLO (US)
Application Number:
PCT/US2013/046290
Publication Date:
July 09, 2015
Filing Date:
June 18, 2013
Export Citation:
Assignee:
UNIV KANSAS (US)
UNIV MICHIGAN (US)
UNIV WAYNE STATE (US)
SANFORD BURNHAM MED RES INST (US)
UNIV MICHIGAN (US)
UNIV WAYNE STATE (US)
SANFORD BURNHAM MED RES INST (US)
International Classes:
C07C311/15; C07D211/08; C07D307/70
Domestic Patent References:
| WO2007084868A2 | 2007-07-26 | |||
| WO2008133734A2 | 2008-11-06 |
Foreign References:
| EP1321454A1 | 2003-06-25 | |||
| US3336307A | 1967-08-15 | |||
| US20110065686A1 | 2011-03-17 |
Other References:
DATABASE PUBCHEM. 15 June 2011 (2011-06-15), retrieved from http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=52940455 accession no. 2940455
LI, Y ET AL.: "Microwave-Assisted Synthesis of Amides from Various Amines and Benzoyl Chloride under Solvent-Free Conditions: A Rapid and Efficient Method for Selective Protection of Diverse Amines'.", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol. 44, no. 3, 2008, pages 358 - 361
LI, Y ET AL.: "Microwave-Assisted Synthesis of Amides from Various Amines and Benzoyl Chloride under Solvent-Free Conditions: A Rapid and Efficient Method for Selective Protection of Diverse Amines'.", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol. 44, no. 3, 2008, pages 358 - 361
Attorney, Agent or Firm:
LICATA, Jane, Massey et al. (66 E. Main StreetMarlton, NJ, US)
Download PDF: