Title:
ACTIVATION OF AMP-PROTEIN ACTIVATED KINASE BY OXALOACETATE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2011/163319
Kind Code:
A3
Abstract:
The present invention relates to oxaloacetate compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds, preserving said compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, obesity, cardiovascular disease, Alzheimer's disease, and cancer.
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Inventors:
CASH ALAN B (US)
Application Number:
PCT/US2011/041377
Publication Date:
April 19, 2012
Filing Date:
June 22, 2011
Export Citation:
Assignee:
CASH ALAN B (US)
International Classes:
A61K31/225; C07C69/34; C07C69/52
Foreign References:
| US20080279786A1 | 2008-11-13 | |||
| US20060281691A1 | 2006-12-14 | |||
| US5914326A | 1999-06-22 | |||
| US20100150895A1 | 2010-06-17 |
Other References:
"CASH Oxaloacetic Acid Supplementation as a Mimic of Calorie Restriction.", OPEN LONGEVITY SCIENCE., vol. 3, 2009, pages 22 - 27
BARTLEY ET AL.: "The Formation of Phosphopyruvate in Washed Particles of Kidney and Liver", BIOCHEM. J., vol. 59, no. 2, February 1955 (1955-02-01), pages 194 - 202
BARTLEY ET AL.: "The Formation of Phosphopyruvate in Washed Particles of Kidney and Liver", BIOCHEM. J., vol. 59, no. 2, February 1955 (1955-02-01), pages 194 - 202, Retrieved from the Internet [retrieved on 20120223]
BARTLEY ET AL.: "The Formation of Phosphopyruvate in Washed Particles of Kidney and Liver", BIOCHEM. J., vol. 59, no. 2, February 1955 (1955-02-01), pages 194 - 202
BARTLEY ET AL.: "The Formation of Phosphopyruvate in Washed Particles of Kidney and Liver", BIOCHEM. J., vol. 59, no. 2, February 1955 (1955-02-01), pages 194 - 202, Retrieved from the Internet
Attorney, Agent or Firm:
TAKAGI, Keiko, K. et al. (Pllc2100 Pennsylvania Avenue, NW, Suite 80, Washington District of Columbia, US)
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