ACTIVATION INHIBITOR FOR TOLL-LIKE RECEPTOR 7 OR TOLL-LIKE RECEPTOR 9

WIPO Patent Application WO/2017/047769

A1

In the present invention, a compound selected from cyclobakuchiol A, cyclobakuchiol B and derivatives thereof, a pharmacologically acceptable salt thereof or a prodrug thereof, is a low molecular weight compound having an action of selectively inhibiting Toll-like receptor 7, or Toll-like receptor 9, and is useful as an active ingredient in an agent for preventing or treating a disease accompanying activation of Toll-like receptor 7, or Toll-like receptor 9.

WO/2023/047317	COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING INFLAMMATORY DISEASES INCLUDING DIABETES AND THYROID DISEASES
JP2006124315	ORAL COMPOSITION
WO/2022/162711	COMPOSITION FOR THE TREATMENT OF PAINFUL AND/OR INFLAMMATORY STATES

TAKATSU KIYOSHI (JP)
NAGAI YOSHINORI (JP)
OKAMOTO NAOKI (JP)
KOBAYASHI YUICHI (JP)
FUJISHITA SHIGETO (JP)

PCT/JP2016/077496

March 23, 2017

September 16, 2016

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NAT UNIV CORP UNIV OF TOYAMA (JP)
TOKYO INST TECH (JP)
TEIKA PHARMACEUTICAL CO LTD (JP)

A61K31/05; A61K31/085; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P5/14; A61P7/04; A61P7/06; A61P9/00; A61P9/10; A61P17/00; A61P17/06; A61P19/02; A61P19/04; A61P21/00; A61P21/04; A61P25/00; A61P25/28; A61P29/00; A61P31/04; A61P37/02; A61P37/04; A61P37/06; A61P43/00; C07C39/23; C07C69/157

JP2008540551A

2008-11-20

BACKHOUSE C. NADINE ET AL.: "Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities", JOURNAL OF ETHNOPHARMACOLOGY, vol. 78, no. 1, 2001, pages 27 - 31, XP009114595, ISSN: 0378-8741
BACKHOUSE C. NADINE ET AL.: "Cyclobakuchiols A and B from Psoralea Glandulosa", PHYTOCHEMISTRY, vol. 40, no. 1, 1995, pages 325 - 327, XP055373645, ISSN: 0031-9422

IWATANI, Ryo (JP)

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