ACTIVATOR OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR &dgr

Title:

ACTIVATOR OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR &dgr

Document Type and Number:

WIPO Patent Application WO/2006/059744

Kind Code:

A1

Abstract:

A compound represented by the general formula (II) below or a salt thereof is used as an activator of peroxisome proliferator activated receptor &dgr . (In the formula, B¹ represents an alkylene having 2-4 carbon atoms; X²¹ and Y²¹ respectively represent a nitrogen atom or a CH; Z¹ represents an oxygen atom or a sulfur atom; R¹¹, R²¹ and R³¹ respectively represent a hydrogen atom, a halogen atom, an alkyl group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms which is substituted by a halogen atom or the like; and both R⁴¹ and R⁵¹ represent hydrogen atoms or alkyl groups having 1-3 carbon atoms.

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Inventors:

SAKUMA SHOGO (JP)
MOCHIDUKI NOBUTAKA (JP)
TAKAHASHI RIE (JP)
TANAKA YUKA (JP)
YAMAKAWA TOMIO (JP)
MASUI SEIICHIRO (JP)

Application Number:

PCT/JP2005/022236

Publication Date:

June 08, 2006

Filing Date:

November 28, 2005

Export Citation:

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Assignee:

NIPPON CHEMIPHAR CO (JP)
SAKUMA SHOGO (JP)
MOCHIDUKI NOBUTAKA (JP)
TAKAHASHI RIE (JP)
TANAKA YUKA (JP)
YAMAKAWA TOMIO (JP)
MASUI SEIICHIRO (JP)

International Classes:

C07D261/20; A61K31/343; A61K31/423; A61K31/4439; A61K31/506; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07D307/79; C07D413/06

Foreign References:

JP2003523336A	2003-08-05
JP2002503203A	2002-01-29

Other References:

DUBOIS G E ET AL: "Dihydrochalcone sweeteners. A study of the atypical temporal phenomena.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 24, no. 4, 1981, pages 408 - 428, XP002345673

Attorney, Agent or Firm:

Chigusa, Shinichi c/o Nippon Chemiphar Co. Ltd. (2-3, Iwamoto-cho 2-chom, Chiyoda-ku Tokyo 32, JP)

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