Title:
ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2009/128558
Kind Code:
A1
Abstract:
Disclosed is a compound represented by general formula (I) or a pharmacologically acceptable salt thereof, which can be used as an activator for a PPAR. (In the formula, R1 and R2 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms and substituted by a halogen atom, or the like; R3, R4, R5 and R6 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like; X represents a sulfur atom or the like; Y represents an oxygen atom, a bond or the like; p represents a number of 0 or 1; A represents an oxygen atom, CH2, N-NH2 or the like; B represents a benzene ring which may have a substituent when p is 1, or B represents a fused ring selected from a benzisoxazole ring which may have a substituent and others when p is 0; m represents an integer of 1 to 4; and n represents an integer of 0 to 5.)
Inventors:
SAKUMA SHOGO (JP)
TAKAHASHI RIE (JP)
NAKAMURA HIDEKI (JP)
TAKAHASHI RIE (JP)
NAKAMURA HIDEKI (JP)
Application Number:
PCT/JP2009/057946
Publication Date:
October 22, 2009
Filing Date:
April 15, 2009
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
SAKUMA SHOGO (JP)
TAKAHASHI RIE (JP)
NAKAMURA HIDEKI (JP)
SAKUMA SHOGO (JP)
TAKAHASHI RIE (JP)
NAKAMURA HIDEKI (JP)
International Classes:
C07D333/56; A61K31/381; A61K31/423; A61P1/04; A61P1/16; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/08; A61P15/00; A61P17/00; A61P17/06; A61P17/10; A61P17/14; A61P19/02; A61P21/04; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07D333/58; C07D413/06
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Other References:
KIDWAI MAZAAHIR ET AL.: "New indolyl phthalazinones and phthalazine derivatives as spermicidal agents", ACTA PHARMACEUTICA (ZAGREB), vol. 47, no. 1, 1997, pages 53 - 57, XP008142394
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See also references of EP 2277874A4
UHLE FREDERICK ET AL.: "Synthesis and cyclization of a-methylamino-p-(4-carboxy-3- indole)propionic acid", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 79, 1957, pages 102 - 109, XP008144178
PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 7335 - 7359
KLIEWER, S.A., NATURE, vol. 358, 1992, pages 771 - 774
See also references of EP 2277874A4
Attorney, Agent or Firm:
CHIGUSA, Shinichi (2-3, Iwamoto-cho 2-chome,Chiyoda-k, Tokyo 32, JP)
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