Title:
ACTIVATORS OF INNATE IMMUNITY
Document Type and Number:
WIPO Patent Application WO/2011/150320
Kind Code:
A3
Abstract:
The present invention includes IFN activating agents that activate expression of IFN-B, activate NF-κΒ expression, activate an innate immune response, activate the expression of one or more cytokines, and/or induce the expression of interferon beta (TFN-β) through a RNase L and/or MDA5-dependent pathway. Such IFN activating agents include single stranded RNAs that encode for conserved region Π of the L protein of a negative stranded RNA virus, including, but not limited to, viruses of the family Paramyxoviridae. Also included are methods of making and using such IFN activating agents and vaccine compositions including such IFN activating agents.
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Inventors:
HE BIAO (US)
LUTHRA PRIYA (US)
LUTHRA PRIYA (US)
Application Number:
PCT/US2011/038313
Publication Date:
May 03, 2012
Filing Date:
May 27, 2011
Export Citation:
Assignee:
UNIV GEORGIA (US)
HE BIAO (US)
LUTHRA PRIYA (US)
HE BIAO (US)
LUTHRA PRIYA (US)
International Classes:
C12N15/113; A61K31/7105; A61K48/00; A61P31/12; A61P35/00; A61P37/00; C12N15/63
Foreign References:
| US20090022761A1 | 2009-01-22 | |||
| US20080317863A1 | 2008-12-25 |
Other References:
LUTHRA, P. ET AL.: "AKT1-Dependent Activation of NF-kB by the L Protein of Parainfluenza Virus 5", JOURNAL OF VIROLOGY, vol. 82, no. 21, 30 November 2008 (2008-11-30), pages 10887 - 10895
TING, J. P. Y. ET AL.: "How the Noninflammasome NLRs Function in the Innate Immune System", SCIENCE, vol. 327, 15 January 2010 (2010-01-15), pages 286 - 290
DATABASE NCBI, GENBANK 3 August 1993 (1993-08-03), "Simian Virus 5 L protein genomic RNA, complete cds", accession no. 81721
TING, J. P. Y. ET AL.: "How the Noninflammasome NLRs Function in the Innate Immune System", SCIENCE, vol. 327, 15 January 2010 (2010-01-15), pages 286 - 290
DATABASE NCBI, GENBANK 3 August 1993 (1993-08-03), "Simian Virus 5 L protein genomic RNA, complete cds", accession no. 81721
Attorney, Agent or Firm:
JOHNSON, Nancy, A. (P.A.P.O. Box 58133, Minneapolis MN, US)
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