Title:
ACTIVITY ENHANCER FOR ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2012/124641
Kind Code:
A1
Abstract:
Provided is an activity enhancer for an anticancer agent, containing, as an active ingredient, a D-amino acid residue-containing FNIII14 polypeptide, which is a polypeptide FNIII14 having an amino acid sequence represented by sequence No. 1, in which at least one of the amino acid residues at positions 1 to 13 is a D-amino acid residue. Also provided is an anticancer composition containing an anticancer agent and the activity enhancer for an anticancer agent.
Inventors:
FUKAI FUMIO (JP)
KODAMA HIROAKI (JP)
MATSUNAGA TAKUYA (JP)
KODAMA HIROAKI (JP)
MATSUNAGA TAKUYA (JP)
Application Number:
PCT/JP2012/056186
Publication Date:
September 20, 2012
Filing Date:
March 09, 2012
Export Citation:
Assignee:
UNIV TOKYO SCI EDUC FOUND (JP)
UNIV SAGA (JP)
UNIV KAGAWA NAT UNIV CORP (JP)
FUKAI FUMIO (JP)
KODAMA HIROAKI (JP)
MATSUNAGA TAKUYA (JP)
UNIV SAGA (JP)
UNIV KAGAWA NAT UNIV CORP (JP)
FUKAI FUMIO (JP)
KODAMA HIROAKI (JP)
MATSUNAGA TAKUYA (JP)
International Classes:
A61K38/00; A61K31/7068; A61P35/00; A61P35/02
Domestic Patent References:
| WO2010140567A1 | 2010-12-09 | |||
| WO2001008698A1 | 2001-02-08 |
Foreign References:
| JP2006327980A | 2006-12-07 | |||
| JP2009118854A | 2009-06-04 | |||
| JPH10147600A | 1998-06-02 | |||
| JP2000026490A | 2000-01-25 | |||
| JP2006327980A | 2006-12-07 | |||
| JP2010043087A | 2010-02-25 | |||
| JPH0673093A | 1994-03-15 |
Other References:
SAYAKA W. ET AL.: "Abrogation of Cell Adhesion- Mediated Drug Resistance (CAM-DR) of Acute Myelogenous Leukemia by Anti-Adhesive Peptide, FNIII14", PEPTIDE SCIENCE, vol. 2009, 2010, pages 325 - 8, XP008171872
FUKAI, F. ET AL.: "Identification of the anti- adhesive site buried within the heparin-binding domain of fibronectin", J BIOCHEM, vol. 121, no. 2, 1997, pages 189 - 192, XP000915473
HIDEKI MIZUNUMA ET AL.: "GnRH Agonist Seizai wa Nanshurui mo Aruga Doshite Sayo no Tsuyosa ni Sa ga Aru noka?", HORM FRONT GYNECOL, vol. 6, no. 4, 1999, pages 108 - 9, XP008171807
LEUKEMIA, vol. 22, 2008, pages 353 - 360
BIOCHEM PHARMCOL., vol. 58, no. 11, 1 December 1999 (1999-12-01), pages 1775 - 80
NEUROPEPTIDES, vol. 5, no. 1-3, December 1984 (1984-12-01), pages 177 - 80
FUKAI ET AL., J. BIOL. CHEM., vol. 266, 1991, pages 8807
DREWINKO, B.; GREEN, C.; LOO, T. L.: "Combination chemotherapy in vitro with cis-dichlorodiammineplatinum (II", CANCER TREAT REP, vol. 60, no. 11, 1976, pages 1619 - 1625
See also references of EP 2716297A4
FUKAI, F. ET AL.: "Identification of the anti- adhesive site buried within the heparin-binding domain of fibronectin", J BIOCHEM, vol. 121, no. 2, 1997, pages 189 - 192, XP000915473
HIDEKI MIZUNUMA ET AL.: "GnRH Agonist Seizai wa Nanshurui mo Aruga Doshite Sayo no Tsuyosa ni Sa ga Aru noka?", HORM FRONT GYNECOL, vol. 6, no. 4, 1999, pages 108 - 9, XP008171807
LEUKEMIA, vol. 22, 2008, pages 353 - 360
BIOCHEM PHARMCOL., vol. 58, no. 11, 1 December 1999 (1999-12-01), pages 1775 - 80
NEUROPEPTIDES, vol. 5, no. 1-3, December 1984 (1984-12-01), pages 177 - 80
FUKAI ET AL., J. BIOL. CHEM., vol. 266, 1991, pages 8807
DREWINKO, B.; GREEN, C.; LOO, T. L.: "Combination chemotherapy in vitro with cis-dichlorodiammineplatinum (II", CANCER TREAT REP, vol. 60, no. 11, 1976, pages 1619 - 1625
See also references of EP 2716297A4
Attorney, Agent or Firm:
NAKAJIMA, Jun et al. (JP)
Nakajima 淳 (JP)
Nakajima 淳 (JP)
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