Title:
ACTIVITY MODULATOR
Document Type and Number:
WIPO Patent Application WO/2019/107445
Kind Code:
A1
Abstract:
The present invention relates to: an activity modulator which is a means for modulating the activity of CD300b dependent phagocytosis; and medicine for the treatment or prevention of a disease or condition in which the activity is involved. The activity modulator comprises a CD300a binding agent and modulates CD300b dependent phagocytosis signals in a macrophage.
Inventors:
SHIBUYA AKIRA (JP)
ODA CHIGUSA (JP)
ABE FUMIE (JP)
FUJIYAMA SATOSHI (JP)
ODA CHIGUSA (JP)
ABE FUMIE (JP)
FUJIYAMA SATOSHI (JP)
Application Number:
PCT/JP2018/043862
Publication Date:
June 06, 2019
Filing Date:
November 28, 2018
Export Citation:
Assignee:
UNIV TSUKUBA (JP)
International Classes:
A61K39/395; A61P1/00; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P25/00; A61P27/02; A61P43/00; C07K16/28; C12N5/0786
Domestic Patent References:
| WO2015025956A1 | 2015-02-26 | |||
| WO2013077186A1 | 2013-05-30 | |||
| WO2014073529A1 | 2014-05-15 | |||
| WO2013077186A1 | 2013-05-30 |
Foreign References:
| JP2014095570A | 2014-05-22 |
Other References:
SHIMHADRI, V. R. ET AL.: "Human CD 300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells", BLOOD, vol. 119, no. 12, 2012, pages 2799 - 2809, XP002732928
CARNEC, X. ET AL.: "The Phosphatidylserine and Phosphatidylethanolamine Receptor CD 300a Binds Dengue Virus and Enhances Infection", J. VIROLOGY, vol. 90, no. 1, 2016, pages 92 - 102, XP055462524
LANKRY, D. ET AL.: "The interaction between CD 300a and phosphatidylserine inhibits tumor cell killing by NK cells", EUR. J. IMMUNOL., vol. 43, 2013, pages 2151 - 2161, XP055153676
NAKAHASHI-ODA, C. ET AL.: "Apoptotic cells suppress mast cell inflammatory responses via the CD 300a immunoreceptor", J. EXP. MED., vol. 209, no. 8, 2012, pages 1493 - 1503, XP055223944
V.A.FADOK ET AL., J IMMUNOL, vol. 148, 1 April 1992 (1992-04-01), pages 2207
J.SAVILLI.DRANSFIELDC.GREGORYC.HASLETT, NAT REV IMMUNOL, vol. 2, 2002, pages 965
NISHI ET AL., MOL. CELL. BIOL. APRIL, vol. 34, no. 8, 2014, pages 1512 - 1520
MURAKAMI ET AL., CELL DEATH AND DIFFERENTIATION, vol. 21, 2014, pages 1746 - 1757
NAKAHASHI-ODA ET AL., J. EXP. MED., vol. 209, pages 1493 - 1503
SHICHITA ET AL., NAT MED, 2016
MAHMOUD ET AL., NAT PROT, 2014
See also references of EP 3718568A4
CARNEC, X. ET AL.: "The Phosphatidylserine and Phosphatidylethanolamine Receptor CD 300a Binds Dengue Virus and Enhances Infection", J. VIROLOGY, vol. 90, no. 1, 2016, pages 92 - 102, XP055462524
LANKRY, D. ET AL.: "The interaction between CD 300a and phosphatidylserine inhibits tumor cell killing by NK cells", EUR. J. IMMUNOL., vol. 43, 2013, pages 2151 - 2161, XP055153676
NAKAHASHI-ODA, C. ET AL.: "Apoptotic cells suppress mast cell inflammatory responses via the CD 300a immunoreceptor", J. EXP. MED., vol. 209, no. 8, 2012, pages 1493 - 1503, XP055223944
V.A.FADOK ET AL., J IMMUNOL, vol. 148, 1 April 1992 (1992-04-01), pages 2207
J.SAVILLI.DRANSFIELDC.GREGORYC.HASLETT, NAT REV IMMUNOL, vol. 2, 2002, pages 965
NISHI ET AL., MOL. CELL. BIOL. APRIL, vol. 34, no. 8, 2014, pages 1512 - 1520
MURAKAMI ET AL., CELL DEATH AND DIFFERENTIATION, vol. 21, 2014, pages 1746 - 1757
NAKAHASHI-ODA ET AL., J. EXP. MED., vol. 209, pages 1493 - 1503
SHICHITA ET AL., NAT MED, 2016
MAHMOUD ET AL., NAT PROT, 2014
See also references of EP 3718568A4
Attorney, Agent or Firm:
SSINPAT PATENT FIRM (JP)
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