Title:
ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) BIOMARKERS
Document Type and Number:
WIPO Patent Application WO/2010/138843
Kind Code:
A3
Abstract:
The present invention concerns the use of biomarkers for acute lymphoblastic leukemia (ALL) to prognose or evaluate a patient with ALL who is Ph+. Methods and compositions are provided that concern these ALL biomarkers. In specific embodiments, methods for determining whether an ALL patient should be treated with standard chemotherapy are provided.
Inventors:
ZUO ZHANG (US)
LUTHRA RAJYALAKSHMI (US)
LUTHRA RAJYALAKSHMI (US)
Application Number:
PCT/US2010/036623
Publication Date:
March 31, 2011
Filing Date:
May 28, 2010
Export Citation:
Assignee:
UNIV TEXAS (US)
ZUO ZHANG (US)
LUTHRA RAJYALAKSHMI (US)
ZUO ZHANG (US)
LUTHRA RAJYALAKSHMI (US)
International Classes:
C12Q1/68; C40B40/08; G01N33/50
Other References:
CHEVALLIER, P. ET AL.: "Combination of chemotherapy and gemtuzumab ozogamicin in adult philadelphia positive acute lymphoblastic leukemia patient harbori ng CD33 expression", INTERNATIONAL JOURNAL OF HEMATOLOGY., vol. 88, no. 2, 1 August 2008 (2008-08-01), pages 209 - 211
LUGTHART, S. ET AL.: "Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leuk emia", CANCER CELL., vol. 7, no. 4, April 2005 (2005-04-01), pages 375 - 386
FLOTHO, C. ET AL.: "A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia", BLOOD., vol. 110, no. 4, 24 April 2007 (2007-04-24), pages 1271 - 1277, XP055143497, DOI: doi:10.1182/blood-2007-01-068478
HOLLEMAN, A. ET AL.: "Gene-expression patterns in drug-resistant acute lympho blastic leukemia cells and response to treatment", NEW ENGLAND JOURNAL OF MEDICINE., vol. 351, no. 6, 5 August 2004 (2004-08-05), pages 533 - 542
CARIO, G. ET AL.: "Distinct gene expression profiles determine molecular treat ment resonse in childhood acute lymphoblastic leukemia", BLOOD., vol. 105, no. 2, 23 September 2004 (2004-09-23), pages 821 - 826
LUGTHART, S. ET AL.: "Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leuk emia", CANCER CELL., vol. 7, no. 4, April 2005 (2005-04-01), pages 375 - 386
FLOTHO, C. ET AL.: "A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia", BLOOD., vol. 110, no. 4, 24 April 2007 (2007-04-24), pages 1271 - 1277, XP055143497, DOI: doi:10.1182/blood-2007-01-068478
HOLLEMAN, A. ET AL.: "Gene-expression patterns in drug-resistant acute lympho blastic leukemia cells and response to treatment", NEW ENGLAND JOURNAL OF MEDICINE., vol. 351, no. 6, 5 August 2004 (2004-08-05), pages 533 - 542
CARIO, G. ET AL.: "Distinct gene expression profiles determine molecular treat ment resonse in childhood acute lymphoblastic leukemia", BLOOD., vol. 105, no. 2, 23 September 2004 (2004-09-23), pages 821 - 826
Attorney, Agent or Firm:
SHISHIMA, Gina, N. (600 Congress Ave. Suite 240, Austin TX, US)
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