ACYL-ACP THIOESTERASES AND MUTANTS THEREOF

Title:

ACYL-ACP THIOESTERASES AND MUTANTS THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/044779

Kind Code:

A3

Abstract:

Novel plant acyl-ACP thioesterase genes of the FatB and FatA classes and proteins encoded by these genes are disclosed. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Expression of the novel and/or mutated FATB and FATA genes is demonstrated in oleaginous microalga host cells. Furthermore, a method for producing an oil elevated in one or more of C12:0, C14:0, C16:0, C18:0 and/or C18: 1 fatty acids includes transforming a cell with novel and/or mutated FATB and/or FATA genes, e.g., having an N-terminal deletion. The cells produce triglycerides with altered and useful fatty acid profiles.

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Inventors:

CASOLARI JASON (US)
ZHAO XINHUA (US)
RUDENKO GEORGE N (US)
FRANKLIN SCOTT (US)

Application Number:

PCT/US2015/051042

Publication Date:

May 12, 2016

Filing Date:

September 18, 2015

Export Citation:

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Assignee:

SOLAZYME INC (US)

International Classes:

C12N9/04; C12N15/52; C12P7/44; C12N5/00

Domestic Patent References:

WO2011008565A1	2011-01-20
WO2011003034A2	2011-01-06
WO2014151904A1	2014-09-25

Other References: