Title:
ACYL-SUBSTITUTED OXAZINO-QUINAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/170086
Kind Code:
A1
Abstract:
Provided are an acyl-substituted oxazino-quinazoline compound, a preparation method therefor, and uses thereof. More particularly provided is a compound shown in formula (I), an isomer, a hydrate, a solvate, a pharmaceutically acceptable salt, a prodrug thereof, a preparation method therefor, and uses thereof in preparing a drug acting as a kinase inhibitor. Said compound has a good inhibitory activity on mutant EGFR kinases and a moderate inhibitory activity on wild-type EGFR kinases. (I)
Inventors:
ZHANG QIANG (CN)
YU SHANNAN (CN)
WANG ZHONGXIANG (CN)
FENG SHOUYE (CN)
ZHENG NANQIAO (CN)
YANG HAILONG (CN)
YANG LEIFU (CN)
ZHANG HONGBO (CN)
ZHOU LIKAI (CN)
YU SHANNAN (CN)
WANG ZHONGXIANG (CN)
FENG SHOUYE (CN)
ZHENG NANQIAO (CN)
YANG HAILONG (CN)
YANG LEIFU (CN)
ZHANG HONGBO (CN)
ZHOU LIKAI (CN)
Application Number:
PCT/CN2019/077026
Publication Date:
September 12, 2019
Filing Date:
March 05, 2019
Export Citation:
Assignee:
BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN)
International Classes:
C07D498/04; A61P35/00
Foreign References:
| CN103965213A | 2014-08-06 | |||
| CN102875570A | 2013-01-16 | |||
| CN104530063A | 2015-04-22 |
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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