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Title:
ACYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2002036556
Kind Code:
A3
Abstract:
The present invention relates to acylaminoalkyl-substituted benzenesulfonamide derivatives of formula (I), in which A, R(1), R(2), X, Y and Z have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmaceutical active compounds which have, for example, an inhibitory action on ATP-sensitive potassium channels in the cardiac muscle and/or in the vagal cardiac nerve and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies, decreased contractility of the heart or vagal dysfunction of the heart, or for the prevention of sudden cardiac death. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use and pharmaceutical preparations comprising them.

Inventors:
HEITSCH HOLGER
ENGLERT HEINRICH CHRISTIAN
Application Number:
EP0112143W
Publication Date:
July 04, 2002
Filing Date:
October 20, 2001
Export Citation:
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Assignee:
AVENTIS PHARMA GMBH (DE)
International Classes:
A61K31/64; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P25/02; A61P43/00; C07C303/36; C07C311/58; C07C335/42; C07D215/54; C07D405/12; C07D407/12; (IPC1-7): C07C311/58; C07C335/42; C07D215/54; C07D407/12; A61K31/64; A61P9/00
Domestic Patent References:
WO2000015204A22000-03-23
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