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Title:
ACYLAMINOPIPERIDINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2007/111227
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a compound that exhibits excellent CCR4 or TARC and/or MDC function regulating activities and can be used in prevention and/or therapy for various inflammatory diseases, allergic diseases, autoimmune diseases, etc. [MEANS FOR SOLVING PROBLEMS] Acylaminopiperidine compounds of the formula (I) or pharmaceutically acceptable salts thereof. (I) In the formula, the characters have the following meaning. A: single bond or C1-C6 alkylene. R1: optionally substituted phenyl, etc. R2: -H or C1-C6 alkyl. R3: -H, C1-C6 alkyl or C3-C8 cycloalkyl. R4: optionally substituted pyrrolidin-2-yl, etc. D: benzene ring or pyrazole ring.

Inventors:
KONTANI TORU (JP)
KAWANO NORIYUKI (JP)
MASUDA NAOYUKI (JP)
KATO KOJI (JP)
NAGATA HIROSHI (JP)
INAMI HIROSHI (JP)
TERASAKA TADASHI (JP)
YOKOYAMA KAZUHIRO (JP)
MIYAZAKI TAKAHIRO (JP)
Application Number:
PCT/JP2007/055943
Publication Date:
October 04, 2007
Filing Date:
March 23, 2007
Export Citation:
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Assignee:
ASTELLAS PHARMA INC (JP)
KONTANI TORU (JP)
KAWANO NORIYUKI (JP)
MASUDA NAOYUKI (JP)
KATO KOJI (JP)
NAGATA HIROSHI (JP)
INAMI HIROSHI (JP)
TERASAKA TADASHI (JP)
YOKOYAMA KAZUHIRO (JP)
MIYAZAKI TAKAHIRO (JP)
International Classes:
A61K31/517; C07D401/14; A61K31/519; A61P1/00; A61P1/04; A61P3/10; A61P11/02; A61P11/06; A61P13/10; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P27/14; A61P29/00; A61P31/04; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D487/04
Domestic Patent References:
WO2005123697A12005-12-29
WO2005082865A12005-09-09
WO2003104230A12003-12-18
WO2003104230A12003-12-18
WO2005082865A12005-09-09
WO2005085212A12005-09-15
WO2005123697A12005-12-29
Foreign References:
JP2005162673A2005-06-23
JP2007055940A2007-03-08
US20040048865A12004-03-11
Other References:
JOURNAL OF IMMUNOLOGY, vol. 166, 2001, pages 103
THE JOURNAL OF CLINICAL INVESTIGATION, vol. 108, 2001, pages 1331
NATURE, vol. 400, 1999, pages 776
ARTHRITIS & RHEUMATISM, vol. 44, 2001, pages 1022
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, 1997, pages 15036
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, 1998, pages 1764
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, 1996, pages 21514
JOURNAL OF EXPERIMENTAL MEDICINE, vol. 185, 1997, pages 1595
IMMUNOLOGY TODAY, vol. 20, 1999, pages 254
THE JOURNAL OF CLINICAL INVESTIGATION, vol. 107, 2001, pages 1357
JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 115, 2000, pages 640
LABORATORY INVESTIGATION, vol. 81, 2001, pages 335
ARTHRITIS & RHEUMATISM, vol. 44, 2001, pages 2750
CLINICAL & EXPERIMENTAL IMMUNOLOGY, vol. 132, 2003, pages 332
PROG. MED., vol. 5, 1985, pages 2157 - 2161
HIROKAWA SHOTEN, IYAKUHIN NO KAIHATSU, vol. 7, 1990
BUNSHI SEKKEI, pages 163 - 198
"Protective Groups in Organic Synthesis", 1999
"Jikken Kagaku Koza", vol. 20, 1992, CHEMICAL SOCIETY OF JAPAN
JAPANESE JOURNAL OF PHARMACOLOGY, vol. 88, 2002, pages 332
IMMUNOLOGY, vol. 98, 1999, pages 345
JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 111, 1998, pages 86
See also references of EP 2000469A4
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (Intellectual Property3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 11, JP)
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