Title:
ACYLATED 6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTENYL AMINES AND THEIR USE AS PHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO2002064546
Kind Code:
A3
Abstract:
The present invention relates to compounds according to the general formula (I) wherein R -R<4> have the meanings given in the description, A is CH2, CHOH or CH(C1C3-alkyl) B, C and D are independently CH2 or CH-(C1-C3-alkyl), and R<5> is an aryl or heteroaryl group, possibly substituted by the substituents listed in the description. These compounds are useful for the manufacture of medicaments for the treatment of cardiovascular diseases, stable or unstable angina pectoris, coronary heart disease, Prinzmetal angina, acute coronary syndrome, heart failure, myocardial infarction, stroke, thrombosis, peripheral artery occlusive disease, endothelial dysfunction, atherosclerosis, restenosis, endothel damage after PTCA, hypertension, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular hypertension, chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, diabetes, diabetes complications, nephropathy, retinopathy, angiogenesis, asthma bronchiale, chronic renal failure, cirrhosis of the liver, osteoporosis, or restricted memory performance or for a restricted ability to learn, or the lowering of cardiovascular risk of postmenopausal women or after intake of contraceptives.
Inventors:
STROBEL HARTMUT
WOHLFART PAULUS
WOHLFART PAULUS
Application Number:
PCT/EP2002/001449
Publication Date:
November 07, 2002
Filing Date:
February 12, 2002
Export Citation:
Assignee:
AVENTIS PHARMA GMBH (DE)
International Classes:
A61K31/166; A61K31/18; A61K31/40; A61K31/404; A61K31/415; C07D249/18; A61K31/4184; A61K31/4192; A61K31/42; A61K31/421; A61K31/426; A61K31/433; A61K31/4365; A61K31/437; A61K31/44; A61K31/4409; A61K31/4439; A61K31/4453; A61K31/455; A61K31/47; A61K31/495; A61K31/496; A61K31/4965; A61K31/498; A61K31/502; A61K31/505; A61K31/506; A61K31/5375; A61K31/5377; A61P1/16; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P15/10; A61P19/10; A61P25/00; A61P27/02; A61P35/00; A61P43/00; C07C233/65; C07C233/74; C07C235/54; C07C237/38; C07C311/08; C07C311/16; C07D207/34; C07D209/08; C07D213/81; C07D213/82; C07D213/84; C07D215/54; C07D231/14; C07D231/38; C07D235/06; C07D235/08; C07D235/10; C07D237/28; C07D239/28; C07D239/42; C07D239/47; C07D239/48; C07D241/24; C07D241/26; C07D241/44; C07D261/18; C07D263/34; C07D277/20; C07D277/56; C07D285/06; C07D285/14; C07D295/14; C07D401/04; C07D401/06; C07D403/04; C07D471/04; C07D495/04; (IPC1-7): C07C233/65; C07C233/74; C07C235/54; A61K31/166; A61P9/00
Domestic Patent References:
| WO2000003746A2 | 2000-01-27 |
Foreign References:
| DE2536509A1 | 1976-03-18 |
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