Title:
ACYLATED OXYNTOMODULIN PEPTIDE ANALOG
Document Type and Number:
WIPO Patent Application WO/2019/035672
Kind Code:
A1
Abstract:
The present invention relates to a novel peptide analog of acylated oxyntomodulin and a pharmaceutical composition for preventing and treating obesity or overweightness, or diabetes accompanied by obesity and overweightness, containing the same, wherein the peptides have dual activation efficacy on receptors of GLP-1/glucagon and increased in vivo half-life, which are superior to those of natural oxyntomodulin, and the pharmaceutical composition containing the same is effective in the treatment of metabolic diseases such as obesity and diabetes.
Inventors:
YANG JAE-SUNG (KR)
LEE KYUNG-SEOK (KR)
CHAE YU-NA (KR)
BAEK GYE-RIM (KR)
KIM TAE-HYOUNG (KR)
JUNG ILL-HUN (KR)
RYU CHAE-LIM (KR)
IM WEON-BIN (KR)
LEE KYUNG-SEOK (KR)
CHAE YU-NA (KR)
BAEK GYE-RIM (KR)
KIM TAE-HYOUNG (KR)
JUNG ILL-HUN (KR)
RYU CHAE-LIM (KR)
IM WEON-BIN (KR)
Application Number:
PCT/KR2018/009425
Publication Date:
February 21, 2019
Filing Date:
August 16, 2018
Export Citation:
Assignee:
DONG A ST CO LTD (KR)
International Classes:
C07K14/575; A61K38/00
Domestic Patent References:
| WO2016049190A1 | 2016-03-31 |
Foreign References:
| KR20120139579A | 2012-12-27 | |||
| KR20120139579A | 2012-12-27 |
Other References:
SWEDBERG, J. E. ET AL.: "Cyclic Alpha-conotoxin Peptidomimetic Chimeras as Potent GLP-1R Agonists", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 103, 2015, pages 175 - 184, XP029295239, DOI: doi:10.1016/j.ejmech.2015.08.046
MURAGE, E. N. ET AL.: "Search for a-helical Propensity in the Receptor-bound Conformation of Glucagon-like Peptide-1", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 2008, pages 10106 - 10112, XP025691312, DOI: doi:10.1016/j.bmc.2008.10.006
MIRANDA, L. P. ET AL.: "Design and Synthesis of Conformationally Constrained Glucagon-like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2758 - 2765, XP007909689, DOI: doi:10.1021/jm701522b
ANIM SCI J., vol. 87, no. 9, 2016, pages 1090 - 1098
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EXPERT REV CARDIOVASC THER., vol. 13, no. 7, 2015, pages 753 - 767
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DIABETES, vol. 62, no. 1, 2013, pages A48
J CLIN ENDOCRINOL METAB., vol. 88, 2003, pages 4696 - 4701
MOLECULAR METABOLISM., vol. 3, 2014, pages 241 - 251
J BIOL CHEM., vol. 278, 2002, pages 22418 - 22423
MOLECULAR METABOLISM, vol. 2, 2013, pages 468 - 479
ACS CHEM BIOL., vol. 11, 2016, pages 324 - 328
DIABETES, OBESITY AND METABOLISM, vol. 18, 2016, pages 1176 - 1190
LANCET, vol. 391, 2018, pages 2607 - 2618
MURAGE, E. N. ET AL.: "Search for a-helical Propensity in the Receptor-bound Conformation of Glucagon-like Peptide-1", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 2008, pages 10106 - 10112, XP025691312, DOI: doi:10.1016/j.bmc.2008.10.006
MIRANDA, L. P. ET AL.: "Design and Synthesis of Conformationally Constrained Glucagon-like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2758 - 2765, XP007909689, DOI: doi:10.1021/jm701522b
ANIM SCI J., vol. 87, no. 9, 2016, pages 1090 - 1098
PHYSIOL REV., vol. 87, no. 4, 2007, pages 1409 - 1439
EXPERT REV CARDIOVASC THER., vol. 13, no. 7, 2015, pages 753 - 767
KOREAN J MED., vol. 87, no. 1, 2014, pages 9 - 13
DIABETES, vol. 58, no. 10, 2009, pages 2258 - 2266
DIABETES, vol. 54, 2005, pages 2390 - 2395
DIABETES, vol. 62, no. 1, 2013, pages A48
J CLIN ENDOCRINOL METAB., vol. 88, 2003, pages 4696 - 4701
MOLECULAR METABOLISM., vol. 3, 2014, pages 241 - 251
J BIOL CHEM., vol. 278, 2002, pages 22418 - 22423
MOLECULAR METABOLISM, vol. 2, 2013, pages 468 - 479
ACS CHEM BIOL., vol. 11, 2016, pages 324 - 328
DIABETES, OBESITY AND METABOLISM, vol. 18, 2016, pages 1176 - 1190
LANCET, vol. 391, 2018, pages 2607 - 2618
Attorney, Agent or Firm:
ROH, Jae-Chull (KR)
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