Title:
ACYLGUANIDINE DERIVATIVE OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/018168
Kind Code:
A1
Abstract:
It is intended to provide a compound which can be used for preventing and/or treating a disease associated with 5HT2B receptor and 5HT7 receptor, particularly for treating irritable bowel syndrome (IBS) and/or preventing migraine. It was found that an acylguanidine derivative characterized by having a tricyclic structure or a pharmaceutically acceptable salt thereof has a strong antagonism to 5HT2B receptor and 5HT7 receptor. In addition, the compound of the invention having the antagonism to both receptors showed a better pharmacological action compared to the case where an antagonist selective to one of the receptors was solely used. From the above results, the compound of the invention is useful for preventing and/or treating a disease associated with 5HT2B receptor and 5HT7 receptor, particularly for treating irritable bowel syndrome (IBS) and/or preventing migraine.
Inventors:
YAMADA HIROYOSHI (JP)
ITAHANA HIROTSUNE (JP)
MORITOMO AYAKO (JP)
MATSUZAWA TAKAHO (JP)
NOZAWA EISUKE (JP)
AKUZAWA SHINOBU (JP)
HARADA KOICHIRO (JP)
ITAHANA HIROTSUNE (JP)
MORITOMO AYAKO (JP)
MATSUZAWA TAKAHO (JP)
NOZAWA EISUKE (JP)
AKUZAWA SHINOBU (JP)
HARADA KOICHIRO (JP)
Application Number:
PCT/JP2006/315576
Publication Date:
February 15, 2007
Filing Date:
August 07, 2006
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
YAMADA HIROYOSHI (JP)
ITAHANA HIROTSUNE (JP)
MORITOMO AYAKO (JP)
MATSUZAWA TAKAHO (JP)
NOZAWA EISUKE (JP)
AKUZAWA SHINOBU (JP)
HARADA KOICHIRO (JP)
YAMADA HIROYOSHI (JP)
ITAHANA HIROTSUNE (JP)
MORITOMO AYAKO (JP)
MATSUZAWA TAKAHO (JP)
NOZAWA EISUKE (JP)
AKUZAWA SHINOBU (JP)
HARADA KOICHIRO (JP)
International Classes:
C07D209/88; A61K31/381; A61K31/385; A61K31/403; A61K31/407; A61K31/435; A61K31/437; A61K31/438; A61K31/454; A61K31/5377; A61K31/538; A61P1/00; A61P25/06; A61P43/00; C07D221/16; C07D265/38; C07D333/78; C07D401/04; C07D403/04; C07D405/04; C07D405/06; C07D413/04; C07D471/04; C07D491/107; C07D495/10
Domestic Patent References:
| WO2005080322A1 | 2005-09-01 | |||
| WO2005079845A1 | 2005-09-01 | |||
| WO2005080322A1 | 2005-09-01 | |||
| WO1999020599A1 | 1999-04-29 | |||
| WO2000017191A2 | 2000-03-30 | |||
| WO2006085510A1 | 2006-08-17 |
Foreign References:
| JP2001520215A | 2001-10-30 | |||
| JP2002502419A | 2002-01-22 | |||
| JPH01132567A | 1989-05-25 |
Other References:
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 439, 2002, pages 1 - 11
REGIONAL ANESTHESIA, vol. 21, 1996, pages 219 - 225
See also references of EP 1923387A4
REGIONAL ANESTHESIA, vol. 21, 1996, pages 219 - 225
See also references of EP 1923387A4
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (Intellectual Property 3-11, Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, JP)
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