Title:
ACYLGUANIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/090304
Kind Code:
A1
Abstract:
Disclosed is an excellent agent for treatment or prevention of dementia, schizophrenia and the like, which has a serotonin 5-HT5A receptor modulating activity. An acylguanidine derivative represented by formula (I), wherein guanidine is bonded to one ring of phthalene via a carbonyl group, and a cyclic group is bonded to the other ring of phthalene, is confirmed to have a strong serotonin 5-HT5A receptor modulating activity and an excellent pharmacological effect due to the serotonin 5-HT5A receptor modulating activity. Consequently, the acylguanidine derivative is useful as a good agent for treatment or prevention of dementia, schizophrenia, bipolar disorder and attention deficit hyperactivity disorder.
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Inventors:
KINOYAMA ISAO (JP)
MIYAZAKI TAKEHIRO (JP)
KOGANEMARU YOHEI (JP)
SHIRAISHI NOBUYUKI (JP)
KAWAMOTO YUICHIRO (JP)
WASHIO TAKUYA (JP)
MIYAZAKI TAKEHIRO (JP)
KOGANEMARU YOHEI (JP)
SHIRAISHI NOBUYUKI (JP)
KAWAMOTO YUICHIRO (JP)
WASHIO TAKUYA (JP)
Application Number:
PCT/JP2010/051756
Publication Date:
August 12, 2010
Filing Date:
February 08, 2010
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
KINOYAMA ISAO (JP)
MIYAZAKI TAKEHIRO (JP)
KOGANEMARU YOHEI (JP)
SHIRAISHI NOBUYUKI (JP)
KAWAMOTO YUICHIRO (JP)
WASHIO TAKUYA (JP)
KINOYAMA ISAO (JP)
MIYAZAKI TAKEHIRO (JP)
KOGANEMARU YOHEI (JP)
SHIRAISHI NOBUYUKI (JP)
KAWAMOTO YUICHIRO (JP)
WASHIO TAKUYA (JP)
International Classes:
C07C279/22; A61K31/085; A61K31/167; A61K31/192; A61K31/216; A61K31/235; A61K31/277; A61K31/341; A61K31/351; A61K31/36; A61K31/366; A61K31/381; A61K31/404; A61K31/415; A61K31/423; A61K31/4245; A61K31/426; A61K31/44; A61K31/47; A61K31/472; A61K31/505; A61P25/18; A61P25/28; A61P43/00; C07D209/18; C07D213/56; C07D213/61; C07D213/64; C07D213/68; C07D213/84; C07D215/14; C07D217/02; C07D231/12; C07D231/16; C07D239/26; C07D263/56; C07D271/06; C07D271/12; C07D277/20; C07D277/30; C07D307/80; C07D309/22; C07D317/60; C07D317/62; C07D319/18; C07D333/08
Domestic Patent References:
| WO2009022633A1 | 2009-02-19 |
Foreign References:
| JP2008543886A | 2008-12-04 | |||
| JPH1081664A | 1998-03-31 |
Other References:
A. DE MEIJERE, F. DIEDERICH ET AL.: "Metal-Catalyzed Cross-Coupling Reactions", 1997, VCH PUBLISHERS INC.
"Courses in Experimental Chemistry", vol. 13, 2005, MARUZEN
P. G. M. WUTS, T. W. GREENE: "Green's Protective Groups in Organic Synthesis", 2006
See also references of EP 2394987A4
"Courses in Experimental Chemistry", vol. 13, 2005, MARUZEN
P. G. M. WUTS, T. W. GREENE: "Green's Protective Groups in Organic Synthesis", 2006
See also references of EP 2394987A4
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
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