ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS

Title:

ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS

Document Type and Number:

WIPO Patent Application WO1999038841

Kind Code:

A8

Abstract:

A compound of formula (1), wherein R1, R2, R3, R4 and R5 are independently selected from hydrogen, alkyl and aryl; and prodrugs thereof; and pharmaceutically acceptable salts thereof; and use of the compounds in therapy, particularly for treatment of a condition generally associated with abnormalities in glutamatergic transmission.

Inventors:

MONCK NATHANIEL JULIUS THOMAS (GB)
GILLESPIE ROGER JOHN (GB)
BIRD ANDREW JAMES (GB)

Application Number:

PCT/GB1999/000321

Publication Date:

October 12, 2000

Filing Date:

February 01, 1999

Export Citation:

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Assignee:

VERNALIS RESEARCH LIMITED (GB)
MONCK NATHANIEL JULIUS THOMAS (GB)
GILLESPIE ROGER JOHN (GB)
BIRD ANDREW JAMES (GB)

International Classes:

A61K31/155; A61K31/381; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P43/00; C07C257/16; C07D333/24; (IPC1-7): C07C257/16; C07D333/24; A61K31/155

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