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Title:
ADAMANTYL DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME
Document Type and Number:
WIPO Patent Application WO2006074244
Kind Code:
A3
Abstract:
The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

Inventors:
PATEL JYOTI R (US)
SHUAI QI (US)
LINK JAMES T (US)
ROHDE JEFFREY J (US)
DINGES JURGEN (US)
SORENSEN BRYAN K (US)
WINN MARTIN (US)
YONG HONG (US)
YEH VINCE S (US)
Application Number:
PCT/US2006/000210
Publication Date:
September 28, 2006
Filing Date:
January 05, 2006
Export Citation:
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Assignee:
ABBOTT LAB (US)
PATEL JYOTI R (US)
SHUAI QI (US)
LINK JAMES T (US)
ROHDE JEFFREY J (US)
DINGES JURGEN (US)
SORENSEN BRYAN K (US)
WINN MARTIN (US)
YONG HONG (US)
YEH VINCE S (US)
International Classes:
C07C235/14; A61K31/4402; A61P3/10; C07C317/16; C07C323/41; C07D207/48; C07D213/64; C07D233/54; C07D257/04; C07D261/08
Domestic Patent References:
WO2004056745A22004-07-08
WO2006024627A22006-03-09
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