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Patent Searching and Data


Title:
ADAMANTYLMETHYLAMINE DERIVATIVE AND USE OF SAME AS PHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2018/181986
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for treating or preventing cognitive function disease or disorder, the composition comprising a compound represented by formula (I), an enantiomer thereof, a diastereomer thereof, or a pharmaceutically acceptable salt thereof.

Inventors:
MORIGUCHI, Shigeki (2-1-1 Katahira, Aoba-ku, Sendai-sh, Miyagi 77, 〒9808577, JP)
FUKUNAGA, Kohji (2-1-1 Katahira, Aoba-ku, Sendai-sh, Miyagi 77, 〒9808577, JP)
IWABUCHI, Yoshiharu (2-1-1 Katahira, Aoba-ku, Sendai-sh, Miyagi 77, 〒9808577, JP)
Application Number:
JP2018/013853
Publication Date:
October 04, 2018
Filing Date:
March 30, 2018
Export Citation:
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Assignee:
TOHOKU UNIVERSITY (2-1-1, Katahira Aoba-ku, Sendai-sh, Miyagi 77, 〒9808577, JP)
International Classes:
C07C211/29; A61K31/137; A61K31/165; A61K31/17; A61K31/18; A61K31/27; A61K31/4402; A61K31/4406; A61P3/10; A61P25/16; A61P25/18; A61P25/28; A61P43/00; C07C215/38; C07C233/05; C07C233/13; C07C233/18; C07C235/06; C07C237/06; C07C271/14; C07C275/28; C07C311/09; C07C311/16; C07C323/41; C07D213/40; C07D213/81
Domestic Patent References:
WO2017131097A12017-08-03
Foreign References:
JP2010519304A2010-06-03
JP2008525425A2008-07-17
CN107556244A2018-01-09
Other References:
DATABASE REGISTRY [online] 2015, retrieved from STN Database accession no. RN1782740-93-5
DATABASE REGISTRY 2016, retrieved from STN Database accession no. RN1981386-54-2
LACHENICHT, S. ET AL.: "Synthesis of Modified 4H-1,2,4-Benzothiadiazine-1,1-dioxides and Determination of their Affinity and Selectivity for Different Types of KATP Channels", CHEMMEDCHEM, vol. 4, no. 11, 2009, pages 1850 - 1858, XP055553106, DOI: doi:10.1002/cmdc.200900261
MORIGUCHI, S. ET AL.: "Blockade of the KATP channel Kir6. 2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy", MOLECULAR PSYCHIATRY, vol. 23, no. 2, 2016, pages 211 - 221, XP055553101
TERAMOTO, N.: "Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K+ Channels", CARDIOVASCULAR DRUG REVIEWS, vol. 24, no. 1, 2006, pages 25 - 32, XP055553127, DOI: doi:10.1111/j.1527-3466.2006.00025.x
Attorney, Agent or Firm:
ONO, Shinjiro et al. (YUASA AND HARA, Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, 〒1000004, JP)
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