Title:
ADAPTER MOLECULE FOR IMPROVEMENT OF T-CELL FUNCTION
Document Type and Number:
WIPO Patent Application WO/2017/221850
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a means for enhancing the function of cytotoxic T cells used for cytotoxic T-cell therapy. Provided by the present invention are: an artificial T-cell activation molecule that includes a CD3ζ extracellular domain, a transmembrane region, and an intracellular signal domain for T-cell activation; and a therapy using the same.
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Inventors:
TERAKURA SEITARO (JP)
KIYOI HITOSHI (JP)
MIYAO KOTARO (JP)
KIYOI HITOSHI (JP)
MIYAO KOTARO (JP)
Application Number:
PCT/JP2017/022414
Publication Date:
December 28, 2017
Filing Date:
June 16, 2017
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
International Classes:
C12N15/09; A61K35/17; A61P31/12; A61P35/00; C07K14/725; C07K19/00; C12N5/0783; C12N5/10
Domestic Patent References:
| WO1997035004A1 | 1997-09-25 |
Foreign References:
| JPH11123082A | 1999-05-11 | |||
| JP2015527070A | 2015-09-17 |
Other References:
YOZO NAKAZAWA: "Gene modified T-cell therapy using chimeric antigen receptor", THE SHINSHU MEDICAL JOURNAL, vol. 61, no. 4, 2013, pages 197 - 203, XP055516593, DOI: 10.11441/shinshumedj.61.197
M. WEISSMAN ALLAN ET AL.: "Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies", THE EMBO JOURNAL, vol. 8, 1989, pages 3651 - 3656, XP000068436
M.WEISSMAN ALLA N ET AL.: "Molecular cloning and chromosomal localization of the human T- cell receptor zeta chain: Distinction from the molecular CD 3 complex", PROC. NATL. ACAD. SCI, vol. 85, no. 24, December 1988 (1988-12-01), pages 9709 - 9713, XP055601816, ISSN: 0027-8424, DOI: 10.1073/pnas.85.24.9709
G. ORLOFF DAVID: "Biochemical Characterization of the eta Chain of the T- cell Receptor", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 264, no. 25, 5 September 1989 (1989-09-05), pages 14812 - 14817, XP055601845
ZHANG TONG ET AL.: "Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T- cell function", CANCER GENE THERAPY, vol. 11, 2004, pages 487 - 496, XP002625514, DOI: doi:10.1038/SJ.CGT.7700703
HOMBACH ANDREAS ET AL.: "Tumor-Specific T Cell Activation by Recombinant Immunoreceptors: CDS zeta Signaling and CD 28 Costimulation Are Stimultaneously Required for Efficient IL -2 Secretion and Can Be Integrated Into One Combined CD 28/ CD 3 zeta Signaling Receptor Molecule", THE JOURNAL OF IMMUNOLOGY, vol. 167, no. 11, December 2001 (2001-12-01), pages 6123 - 6131, XP055083123, ISSN: 0022-1767, DOI: 10.4049/jimmunol.167.11.6123
M. WEISSMAN ALLAN ET AL.: "Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies", THE EMBO JOURNAL, vol. 8, 1989, pages 3651 - 3656, XP000068436
M.WEISSMAN ALLA N ET AL.: "Molecular cloning and chromosomal localization of the human T- cell receptor zeta chain: Distinction from the molecular CD 3 complex", PROC. NATL. ACAD. SCI, vol. 85, no. 24, December 1988 (1988-12-01), pages 9709 - 9713, XP055601816, ISSN: 0027-8424, DOI: 10.1073/pnas.85.24.9709
G. ORLOFF DAVID: "Biochemical Characterization of the eta Chain of the T- cell Receptor", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 264, no. 25, 5 September 1989 (1989-09-05), pages 14812 - 14817, XP055601845
ZHANG TONG ET AL.: "Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T- cell function", CANCER GENE THERAPY, vol. 11, 2004, pages 487 - 496, XP002625514, DOI: doi:10.1038/SJ.CGT.7700703
HOMBACH ANDREAS ET AL.: "Tumor-Specific T Cell Activation by Recombinant Immunoreceptors: CDS zeta Signaling and CD 28 Costimulation Are Stimultaneously Required for Efficient IL -2 Secretion and Can Be Integrated Into One Combined CD 28/ CD 3 zeta Signaling Receptor Molecule", THE JOURNAL OF IMMUNOLOGY, vol. 167, no. 11, December 2001 (2001-12-01), pages 6123 - 6131, XP055083123, ISSN: 0022-1767, DOI: 10.4049/jimmunol.167.11.6123
Attorney, Agent or Firm:
HAGINO Mikiharu (JP)
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