Title:
ADENO-ASSOCIATED VIRAL (AAV)-MEDIATED SPHINGOSINE-1-PHOSPHATE LYASE (SPL) EXPRESSION FOR TREATING PULMONARY FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2023/015189
Kind Code:
A3
Abstract:
The present disclosure provides methods treating or preventing pulmonary fibrosis in a subject in need thereof by administering to the subject a therapeutically effective dose of a recombinant adeno-associated viral (rAAV) virion comprising a nucleic acid encoding sphingosine-1-phosphate lyase (SPL), where administering the rAAV virion results in expression of the SPL in the subject thereby treating or preventing the pulmonary fibrosis in the subject.
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Inventors:
SABA JULIE D (US)
BHATTACHARYA MALLAR (US)
BHATTACHARYA MALLAR (US)
Application Number:
PCT/US2022/074437
Publication Date:
March 16, 2023
Filing Date:
August 02, 2022
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
SABA JULIE D (US)
BHATTACHARYA MALLAR (US)
SABA JULIE D (US)
BHATTACHARYA MALLAR (US)
International Classes:
A61K38/51; A61K48/00; C12N9/88; C12N15/864; A61P11/00
Domestic Patent References:
| WO2020113034A1 | 2020-06-04 |
Other References:
HUANG LONG SHUANG, BERDYSHEV EVGENY V, TRAN JOHN T, XIE LISHI, CHEN JIWANG, EBENEZER DAVID L, MATHEW BIJI, GORSHKOVA IRINA, ZHANG : "Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy", THORAX, BMJ PUBLISHING GROUP, GB, vol. 70, no. 12, 1 December 2015 (2015-12-01), GB , pages 1138 - 1148, XP093047099, ISSN: 0040-6376, DOI: 10.1136/thoraxjnl-2014-206684
SHEA BARRY S., TAGER ANDREW M.: "Role of the Lysophospholipid Mediators Lysophosphatidic Acid and Sphingosine 1-Phosphate in Lung Fibrosis", AMERICAN THORACIC SOCIETY. PROCEEDINGS, AMERICAN THORACIC SOCIETY, NEW YORK,, US, vol. 9, no. 3, 15 July 2012 (2012-07-15), US , pages 102 - 110, XP093047100, ISSN: 1546-3222, DOI: 10.1513/pats.201201-005AW
SHEA BARRY S., TAGER ANDREW M.: "Role of the Lysophospholipid Mediators Lysophosphatidic Acid and Sphingosine 1-Phosphate in Lung Fibrosis", AMERICAN THORACIC SOCIETY. PROCEEDINGS, AMERICAN THORACIC SOCIETY, NEW YORK,, US, vol. 9, no. 3, 15 July 2012 (2012-07-15), US , pages 102 - 110, XP093047100, ISSN: 1546-3222, DOI: 10.1513/pats.201201-005AW
Attorney, Agent or Firm:
CHANDRA, Shweta (US)
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