Title:
ADENO-ASSOCIATED VIRAL VECTOR COMPOSITIONS AND METHODS OF PROMOTING MUSCLE REGENERATION
Document Type and Number:
WIPO Patent Application WO/2023/004332
Kind Code:
A3
Abstract:
Provided are compositions comprising, and methods of administering, gene therapy vectors, particularly recombinant AAV vectors encoding AUF1 proteins for expression in muscle cells for restoring or increasing muscle mass, muscle function or performance, and/or reducing or reversing muscle atrophy. The compositions and methods may be used for the treatment of subject suffering from sarcopenia, muscle degenerative disease or traumatic injury.
Inventors:
ABBADI DOUNIA (US)
SCHNEIDER ROBERT (US)
SCHNEIDER ROBERT (US)
Application Number:
PCT/US2022/073910
Publication Date:
March 09, 2023
Filing Date:
July 19, 2022
Export Citation:
Assignee:
UNIV NEW YORK (US)
International Classes:
A61K48/00; A61P21/00; C12N15/86
Domestic Patent References:
| WO2016196350A1 | 2016-12-08 |
Foreign References:
| CN112515113A | 2021-03-19 |
Other References:
ABBADI DOUNIA ET AL: "Muscle development and regeneration controlled by AUF1-mediated stage-specific degradation of fate-determining checkpoint mRNAs", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 23, 4 June 2019 (2019-06-04), pages 11285 - 11290, XP093017708, ISSN: 0027-8424, Retrieved from the Internet DOI: 10.1073/pnas.1901165116
Attorney, Agent or Firm:
BRIVANLOU, Margaret et al. (US)
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