Title:
ADENO-ASSOCIATED VIRUS CAPSID
Document Type and Number:
WIPO Patent Application WO/2023/072181
Kind Code:
A1
Abstract:
Provided are an AAV capsid having improved liver tissue tropism and stronger exogenous gene expression, and/or improved ability in escaping from neutralizing antibody, the relevant nucleic acid, an AAV particle, a cell containing the nucleic acid and pharmaceutical formulation thereof. Also provided are the use of the AAV capsid, the nucleic acid, the AAV particle, or the pharmaceutical formulation in the manufacture of a drug for delivering a target gene to mammalian cells and a method for treating disease.
Inventors:
XU KAI (CN)
HAN JIABAO (CN)
LI WEI (CN)
TIAN SHIN-SHAY (CN)
ZHAO XIAOPING (CN)
HAN JIABAO (CN)
LI WEI (CN)
TIAN SHIN-SHAY (CN)
ZHAO XIAOPING (CN)
Application Number:
PCT/CN2022/127893
Publication Date:
May 04, 2023
Filing Date:
October 27, 2022
Export Citation:
Assignee:
SHANGHAI VITALGEN BIOPHARMA CO LTD (CN)
International Classes:
C07K14/05; A61K38/16; A61K48/00; C12N15/35; C12N15/864
Foreign References:
| US20180105559A1 | 2018-04-19 | |||
| CN104592364A | 2015-05-06 | |||
| CN105408486A | 2016-03-16 | |||
| US20200002384A1 | 2020-01-02 | |||
| CN107864653A | 2018-03-30 |
Other References:
HAN JIABAO, ZHU LIYU, ZHANG JINGWEN, GUO LU, SUN XUEHAN, HUANG CHENG, XU KAI, ZHANG YING, LI WEI, ZHOU QI: "Rational engineering of adeno‐associated virus capsid enhances human hepatocyte tropism and reduces immunogenicity", CELL PROLIFERATION, OXFORD., GB, vol. 55, no. 12, 1 December 2022 (2022-12-01), GB , XP093060503, ISSN: 0960-7722, DOI: 10.1111/cpr.13339
Attorney, Agent or Firm:
BEIJING HAN KUN LAW OFFICES (CN)
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