ADENO-ASSOCIATED VIRUS PHARMACEUTICAL COMPOSITION AND USE THEREOF

Title:

ADENO-ASSOCIATED VIRUS PHARMACEUTICAL COMPOSITION AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/236964

Kind Code:

A1

Abstract:

Provided is a pharmaceutical composition, the pharmaceutical composition comprising a recombinant adeno-associated virus (AAV), a buffer solution, an amino acid, a stabilizer, and a nonionic surfactant. The pharmaceutical composition has good stability.

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Inventors:

KE XIAO (CN)
ZHENG QIANG (CN)
JIANG HAO (CN)
QIN YINGFEI (CN)
LUO JUNBO (CN)

Application Number:

PCT/CN2023/098693

Publication Date:

December 14, 2023

Filing Date:

June 06, 2023

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Assignee:

CHENGDU ORIGEN BIOTECHNOLOGY CO LTD (CN)

International Classes:

A61K35/761; A61K48/00; A61K47/12; A61K47/18; A61K47/26; A61P27/02

Foreign References:

CN114903922A	2022-08-16
CN110300591A	2019-10-01
CN113164597A	2021-07-23
CN111770999A	2020-10-13

Other References:

SRIVASTAVA ARVIND, MALLELA KRISHNA M.G., DEORKAR NANDKUMAR, BROPHY GER: "Manufacturing Challenges and Rational Formulation Development for AAV Viral Vectors", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN CHEMICAL SOCIETY AND AMERICAN PHARMACEUTICAL ASSOCIATION, US, vol. 110, no. 7, US , pages 2609 - 2624, XP055819334, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2021.03.024

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