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Title:
ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK
Document Type and Number:
WIPO Patent Application WO/2018/133854
Kind Code:
A1
Abstract:
Provided are a kind of nucleoside analogue compounds, and compositions comprising these compounds and pentostatin, their use for modulating circadian rhythm, preferably, for shifting circadian phase, and methods for modulating circadian rhythm, preferably, for shifting circadian phase via these compounds or the compositions.

Inventors:
ZHANG ERQUAN (CN)
QI XIANGBING (CN)
JU DAPENG (CN)
ZHAO HAIJIAO (CN)
MEI LONG (CN)
WANG ZHIQIANG (CN)
WU QINGCUI (CN)
Application Number:
PCT/CN2018/073526
Publication Date:
July 26, 2018
Filing Date:
January 20, 2018
Export Citation:
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Assignee:
NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN)
International Classes:
C07H19/16; A61K31/7052; A61K31/7056; A61K31/7076; A61P25/00; C07H19/00; C07H19/14; C07H19/167; C07H19/173; C07H19/20; C07H19/213
Domestic Patent References:
WO2017178820A12017-10-19
WO2007135387A12007-11-29
Other References:
SIGWORTH, L. A. ET AL.: "Adenosine A1 receptors regulate the response of the mouse circadian clock to light", BRAIN RESEARCH, vol. 960, no. 1, 2, 31 December 2003 (2003-12-31), pages 246 - 251, XP055508455, ISSN: 0006-8993
SLOAN, B.J . ET AL.: "Effect of a novel adenosine deaminase inhibitor (co-vidarabine, co- V) upon the antiviral activity in vitro and in vivo of vidarabine (Vira-A) for DNA virus replication", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 284, 31 December 1977 (1977-12-31), pages 60 - 80, XP055505106, ISSN: 0077-8923
DATABASE REGISTRY 5 December 2011 (2011-12-05), retrieved from STN Database accession no. 1349165-21-4
See also references of EP 3571211A4
Attorney, Agent or Firm:
IPFAITH PARTNERS (CN)
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