Title:
ADENOSINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER, CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2017/052322
Kind Code:
A1
Abstract:
The present invention relates to: an adenosine derivative; a preparation method therefor; and a pharmaceutical composition for preventing or treating cancer, containing the same as an active ingredient. According to the present invention, the adenosine derivative has high affinity and selectivity as an A3 adenosine receptor agonist, and exhibits remarkably excellent tumor growth inhibition efficacy in a cancer cell transplanted nude mouse experimental animal model using liver cancer cell SK-HEP-1, in comparison with a conventionally known A3 adenosine receptor agonist, thereby being useful as a pharmaceutical composition for preventing or treating cancer.
Inventors:
JEONG LAK SHIN (KR)
LEE SANG KOOK (KR)
YU JIN HA (KR)
LEE SANG KOOK (KR)
YU JIN HA (KR)
Application Number:
PCT/KR2016/010746
Publication Date:
March 30, 2017
Filing Date:
September 26, 2016
Export Citation:
Assignee:
FUTURE MEDICINE CO LTD (KR)
International Classes:
C07D473/34; A23L33/10; A61K31/095; A61K31/52; C07D345/00
Domestic Patent References:
| WO2015137983A1 | 2015-09-17 |
Foreign References:
| JP2008195648A | 2008-08-28 |
Other References:
SAHU, P. K. ET AL.: "Stereoselective Synthesis of 4'-Selenonucleosides via Seleno-Michael Reaction as Potent Antiviral Agents", ORGANIC LETTERS, vol. 16, no. 21, 23 October 2014 (2014-10-23), pages 5796 - 5799, XP055371027
YU , J. ET AL.: "New RNA Purine Building Blocks, 4'-Selenoputine Nucleosides: First Synthesis and Unusual Mixture of Sugar Puckerings", CHEMISTRY-A EUROPEAN JOURNAL, vol. 19, 2013, pages 5528 - 5532
JAYAKANTHAN, K. ET AL.: "Stereoselective Synthesis of 4'-selenonucleosides Using the Pummerer Glycosylation Reaction", CARBOHYDRATE RESEARCH, vol. 343, no. 10-11, 21 July 2008 (2008-07-21), pages 1790 - 1800, XP022732670
YU , J. ET AL.: "New RNA Purine Building Blocks, 4'-Selenoputine Nucleosides: First Synthesis and Unusual Mixture of Sugar Puckerings", CHEMISTRY-A EUROPEAN JOURNAL, vol. 19, 2013, pages 5528 - 5532
JAYAKANTHAN, K. ET AL.: "Stereoselective Synthesis of 4'-selenonucleosides Using the Pummerer Glycosylation Reaction", CARBOHYDRATE RESEARCH, vol. 343, no. 10-11, 21 July 2008 (2008-07-21), pages 1790 - 1800, XP022732670
Attorney, Agent or Firm:
KASAN IP & LAW FIRM (KR)
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