Title:
ADENOVIRAL HELPER PLASMID
Document Type and Number:
WIPO Patent Application WO/2022/241215
Kind Code:
A3
Abstract:
Adeno-associated virus (AAV) technology has quickly become a dominant form of gene therapy for genetic diseases. AA Vs can be produced in large scale in a variety of host cell systems, including mammalian cells, such as HEK293 cells. The present disclosure provides improved adenoviral helper plasmids for the production of recombinant adeno-associated viruses. The present disclosure provides an adenoviral helper plasmid comprising nucleotide sequences encoding E2a, VA RNA, E4; and an L4 region.
Inventors:
DISMUKE DAVID (US)
Application Number:
PCT/US2022/029193
Publication Date:
February 02, 2023
Filing Date:
May 13, 2022
Export Citation:
Assignee:
FORGE BIOLOGICS INC (US)
International Classes:
A61K35/761; A61K35/763; A61K38/16; A61P31/22; C07K14/005; C07K14/035; C07K14/075; C12N9/22; C12Q1/70
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Other References:
TAHMASEBI ROOZBEH, DA COSTA ANTONIO CHARLYS, TARDY KAELAN, J. TINKER RORY, DE PADUA MILAGRES FLAVIO AUGUSTO, BRUSTULIN RAFAEL, ROD: "Genomic Analyses of Potential Novel Recombinant Human Adenovirus C in Brazil", VIRUSES, vol. 12, no. 5, pages 508, XP093030951, DOI: 10.3390/v12050508
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SIRENA: "The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3", VIROLOGY, 2005, pages 283 - 298, XP005153505, DOI: 10.1016/j.virol.2005.08.024
Attorney, Agent or Firm:
VETTER, Michael L. et al. (US)
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