Title:
ADENOVIRAL VECTOR COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO2006020480
Kind Code:
A3
Abstract:
Applicants disclose herein novel methods, vectors, and vector compositions for improving the efficiency of adenoviral vectors in the delivery and expression of heterologous nucleic acid encoding a polypeptide(s) (e.g, a protein or antigen) of interest. Adenoviral infection is quite common in the general population, and a large percentage of people have neutralizing antibodies to the more prevalent adenoviral serotypes. Such pre-existing anti-adenoviral immunity can dampen or possibly abrogate the effectiveness of this virus for the delivery and expression of heterologous proteins or antigens. The method taught herein functions to offset pre-existing immunity through the delivery of the protein or antigen by a cocktail of at least two adenoviral serotypes. Utilizing a composition of at least two adenoviral serotypes in this manner has been found to increase the effectiveness of adenoviral administration. Adenoviral vectors of utility in the elicitation of an immune response against Human Immunodeficiency Virus ("HIV") are also disclosed.
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Inventors:
EMINI EMILIO A (US)
SHIVER JOHN W (US)
CASIMIRO DANILO R (US)
BETT ANDREW J (US)
SHIVER JOHN W (US)
CASIMIRO DANILO R (US)
BETT ANDREW J (US)
Application Number:
PCT/US2005/027658
Publication Date:
November 23, 2006
Filing Date:
August 05, 2005
Export Citation:
Assignee:
MERCK & CO INC (US)
EMINI EMILIO A (US)
SHIVER JOHN W (US)
CASIMIRO DANILO R (US)
BETT ANDREW J (US)
EMINI EMILIO A (US)
SHIVER JOHN W (US)
CASIMIRO DANILO R (US)
BETT ANDREW J (US)
International Classes:
C12N15/00; A61K39/12; A61K49/00; C12N7/00; A61K39/00
Other References:
HAIGWOOD N.L.: "Protection from pathogenesis SIV challenge using multigenic DNA vaccines", IMMUNOLOGY LETTERS, vol. 66, 1999, pages 183 - 188, XP008116647
LETVIN N.L.: "Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys", J. OF VIROLOGY, vol. 78, 2004, pages 7490 - 7497, XP008116648
KOJAOGHLANIAN T.: "The impact of adenovirus infection on the immunocompromised host", REVIEW OF MEDICAL VIROLOGY, vol. 13, 2003, pages 155 - 171, XP008116816
RABINOWITZ J.E.: "Cross-packaging of a single adeno-associated virus type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity", J. OF VIROLOGY, vol. 76, 2002, pages 791 - 801, XP002247245
See also references of EP 1786904A4
LETVIN N.L.: "Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys", J. OF VIROLOGY, vol. 78, 2004, pages 7490 - 7497, XP008116648
KOJAOGHLANIAN T.: "The impact of adenovirus infection on the immunocompromised host", REVIEW OF MEDICAL VIROLOGY, vol. 13, 2003, pages 155 - 171, XP008116816
RABINOWITZ J.E.: "Cross-packaging of a single adeno-associated virus type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity", J. OF VIROLOGY, vol. 76, 2002, pages 791 - 801, XP002247245
See also references of EP 1786904A4
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