Title:
ADENOVIRUS VECTORS WITH KNOBLESS FIBERS, AND THEIR USES
Document Type and Number:
WIPO Patent Application WO2001081607
Kind Code:
A3
Abstract:
The present invention provides novel adenoviral vectors, in which the knob of the fiber protein has been removed and replaced with a binding ligand. The invention also provides methods of constructing such vectors and provides uses for such vectors. A modified knobless adenovirus comprising a new binding ligand according to the invention has improved capabilities of entry into specific cell types.
Inventors:
VAN ES HELMUTH HENDRIKUS GERAR (NL)
VAN BEUSECHEM VICTOR WILLEM (NL)
VAN BEUSECHEM VICTOR WILLEM (NL)
Application Number:
PCT/NL2001/000323
Publication Date:
June 13, 2002
Filing Date:
April 26, 2001
Export Citation:
Assignee:
CRUCELL HOLLAND BV (NL)
VRIJE UNIVERSITEIT MEDISCH CT (NL)
ES HELMUTH HENDRIKUS GERARDUS (NL)
BEUSECHEM VICTOR WILLEM VAN (NL)
VRIJE UNIVERSITEIT MEDISCH CT (NL)
ES HELMUTH HENDRIKUS GERARDUS (NL)
BEUSECHEM VICTOR WILLEM VAN (NL)
International Classes:
C07K14/075; C07K14/15; C12N15/861; (IPC1-7): C12N15/86; C12N15/10
Domestic Patent References:
| WO1996026281A1 | 1996-08-29 | |||
| WO1997020051A2 | 1997-06-05 | |||
| WO1999041359A1 | 1999-08-19 | |||
| WO2001002431A1 | 2001-01-11 | |||
| WO1999060147A2 | 1999-11-25 | |||
| WO1999060148A2 | 1999-11-25 | |||
| WO1999064582A2 | 1999-12-16 | |||
| WO1998054346A1 | 1998-12-03 | |||
| WO1998050053A1 | 1998-11-12 | |||
| WO1994010323A1 | 1994-05-11 |
Other References:
VAN BEUSECHEM W ET AL: "Recombinant adenovirus vectors with knobless fibers for targeted gene transfer", GENE THER, vol. 7, no. 22, November 2000 (2000-11-01), pages 1940 - 1946, XP001064437
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