Title:
ADHESION-PREVENTING COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2018/012605
Kind Code:
A1
Abstract:
[Problem] An adhesion-preventing material having a high adhesion-preventing effect has been demanded.
[Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.
Inventors:
ITO TAICHI (JP)
OHTA SEIICHI (JP)
KOKUDO NORIHIRO (JP)
ISAJI MITSUKO (JP)
SHIMIZU SATOSHI (JP)
OHTA SEIICHI (JP)
KOKUDO NORIHIRO (JP)
ISAJI MITSUKO (JP)
SHIMIZU SATOSHI (JP)
Application Number:
PCT/JP2017/025614
Publication Date:
January 18, 2018
Filing Date:
July 13, 2017
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
A61L31/04; A61L31/12; A61L31/14
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Other References:
NAMBA J. ET AL.: "Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART B , APPLIED BIOMATERIALS ., vol. 80, no. 1, 9 June 2006 (2006-06-09) - January 2007 (2007-01-01), pages 273 - 279, XP055602314, ISSN: 1552-4973, DOI: 10.1002/jbm.b.30594
CHATURVEDI A.A. ET AL.: "Prevention of postsurgical adhesions using an ultrapure alginate-based gel.", BRITISH JOURNAL OF SURGERY, vol. 100, no. 7, 2013, pages 904 - 910, XP055296836, ISSN: 0007-1323, DOI: doi:10.1002/bjs.9131
APPL MICROBIOL BIOTECHNOL, vol. 40, 1994, pages 638 - 643
See also references of EP 3485921A4
CHATURVEDI A.A. ET AL.: "Prevention of postsurgical adhesions using an ultrapure alginate-based gel.", BRITISH JOURNAL OF SURGERY, vol. 100, no. 7, 2013, pages 904 - 910, XP055296836, ISSN: 0007-1323, DOI: doi:10.1002/bjs.9131
APPL MICROBIOL BIOTECHNOL, vol. 40, 1994, pages 638 - 643
See also references of EP 3485921A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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