ADHESIVE PATCH AND PRODUCTION METHOD THEREFOR

Title:

ADHESIVE PATCH AND PRODUCTION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2014/017593

Kind Code:

A1

Abstract:

A production method for an adhesive patch comprising a supporting body layer and an adhesive layer, said production method including: a mixture preparation step in which asenapine or a pharmacologically acceptable salt thereof and a sodium acetate having a cumulative volume of 50% in the particle size distribution and a particle diameter (D50) of 40-1,000 µm are mixed such that the particle diameter (D50) of the sodium acetate and sodium diacetate generated from the sodium acetate is no more than 10 µm, and a mixture containing the sodium diacetate and the asenapine or a pharmacologically acceptable salt thereof is obtained; and an adhesive layer forming step in which an adhesive layer composition obtained by mixing the mixture and a pressure-sensitive adhesive base is used and the adhesive layer is formed, said adhesive layer containing the sodium diacetate, asenapine or a pharmacologically acceptable salt thereof, and the pressure-sensitive adhesive base.

Inventors:

SUZUKI MASAYUKI (JP)
OKUTSU HIROAKI (JP)
YASUKOCHI TAKASHI (JP)
TAKADA YASUNORI (JP)

Application Number:

PCT/JP2013/070195

Publication Date:

January 30, 2014

Filing Date:

July 25, 2013

Export Citation:

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Assignee:

HISAMITSU PHARMACEUTICAL CO (JP)

International Classes:

A61K31/407; A61K9/70; A61K47/12; A61K47/32; A61P25/18

Domestic Patent References:

WO2009110351A1	2009-09-11
WO2010127674A1	2010-11-11
WO2000061120A1	2000-10-19
WO2001007018A1	2001-02-01
WO2001007018A1	2001-02-01
WO2005115355A1	2005-12-08
WO2010127674A1	2010-11-11

Foreign References:

JPH11302161A	1999-11-02
JPS62126119A	1987-06-08

Other References: