Title:
ADIPONECTIN VARIANTS
Document Type and Number:
WIPO Patent Application WO2007008937
Kind Code:
A8
Abstract:
An adiponectin variant comprising one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of said variant is improved by at least 3-fold relative to residues 110-244 of SEQ ID NO:1 (human adiponectin). Said adiponectin variant may not comprise residues 1-100 relative to SEQ ID NO:1.
Inventors:
ZALEVSKY JONATHAN (US)
NGUYEN DUC-HANH THI (US)
MOORE GREGORY L (US)
EZHEVSKY SERGEI A (US)
DESJARLAIS JOHN R (US)
CHIRINO ARTHUR J (US)
CASH DARIAN (US)
BERNETT MATTHEW J (US)
NGUYEN DUC-HANH THI (US)
MOORE GREGORY L (US)
EZHEVSKY SERGEI A (US)
DESJARLAIS JOHN R (US)
CHIRINO ARTHUR J (US)
CASH DARIAN (US)
BERNETT MATTHEW J (US)
Application Number:
PCT/US2006/026971
Publication Date:
April 12, 2007
Filing Date:
July 11, 2006
Export Citation:
Assignee:
XENCOR INC (US)
ZALEVSKY JONATHAN (US)
NGUYEN DUC-HANH THI (US)
MOORE GREGORY L (US)
EZHEVSKY SERGEI A (US)
DESJARLAIS JOHN R (US)
CHIRINO ARTHUR J (US)
CASH DARIAN (US)
BERNETT MATTHEW J (US)
ZALEVSKY JONATHAN (US)
NGUYEN DUC-HANH THI (US)
MOORE GREGORY L (US)
EZHEVSKY SERGEI A (US)
DESJARLAIS JOHN R (US)
CHIRINO ARTHUR J (US)
CASH DARIAN (US)
BERNETT MATTHEW J (US)
International Classes:
C07K14/47; C07K14/575; A61P3/04; A61P3/10; A61P9/12
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