ADJUSTED MULTI-BIOMARKER DISEASE ACTIVITY SCORE FOR INFLAMMATORY DISEASE ASSESSMENT

WIPO Patent Application WO/2019/027910

A3

Provided herein are methods for assessing response to inflammatory disease therapy. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers to assess disease activity in inflammatory diseases, e.g., rheumatoid arthritis. Also provided are methods of adjusting disease activity scores to account for variables that can influence such scores.

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FLAKE DARL (US)
GUTIN ALEXANDER (US)
LANCHBURY JERRY (US)
CHERNOFF DAVID (US)
EASTMAN PAUL SCOTT (US)
HWANG CHING CHANG (US)
SASSO ERIC (US)

PCT/US2018/044396

April 04, 2019

July 30, 2018

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FLAKE DARL (US)
GUTIN ALEXANDER (US)
LANCHBURY JERRY (US)
CHERNOFF DAVID (US)
EASTMAN PAUL SCOTT (US)
HWANG CHING CHANG (US)
SASSO ERIC (US)
MYRIAD GENETICS INC (US)

A61K35/14; A61K35/16; A61P29/00

WO2017059003A1	2017-04-06
WO2015191423A1	2015-12-17

US20110137851A1

2011-06-09

LEE, SANG-WON ET AL.: "Measurement of the serum leptin level could assist disease activity monitoring in rheumatoid arthritis", RHEUMATOLOGY INTERNATIONAL, vol. 27, no. 6, 2007, pages 537 - 540, XP019490226
CURTIS, JEFFREY R. ET AL.: "Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity", ARTHRITIS CARE & RESEARCH, vol. 64, no. 12, 2012, pages 1794 - 1803, XP055154258, DOI: doi:10.1002/acr.21767

ELLIS, Gregory C. (US)

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