Title:
ADJUVANT COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/209274
Kind Code:
A1
Abstract:
The present invention provides an adjuvant that can induce immunostimulation, particularly T cell immunostimulation. The present invention provides an adjuvant that can particularly induce antigen-specific immunostimulation, particularly T cell immunostimulation.
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Inventors:
FUJII SHINICHIRO (JP)
SHIMIZU KANAKO (JP)
SHIMIZU KANAKO (JP)
Application Number:
PCT/JP2017/020576
Publication Date:
December 07, 2017
Filing Date:
June 02, 2017
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
A61K39/39; A61K39/00; A61P35/00; A61P37/04; A61P43/00; C07K19/00; C12N5/16; C12N9/64; C12N15/09
Foreign References:
| JP2004535202A | 2004-11-25 |
Other References:
MARTINA, J A ET AL.: "Imaging of lytic granule exocytosis in CD 8+ cytotoxic T lymphocytes reveals a modified form of full fusion", CELL IMMUNOL, vol. 271, no. 2, 2011, pages 267 - 279, XP028314554, DOI: doi:10.1016/j.cellimm.2011.07.004
HAYES, M P ET AL.: "Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A", J EXP MED, vol. 170, no. 3, 1989, pages 933 - 946, XP000653476, DOI: doi:10.1084/jem.170.3.933
POWELL, T J ET AL.: "Examination of influenza specific T cell responses after influenza virus challenge in individuals vaccinated with MVA-NP+M1 vaccine", PLOS ONE, vol. 8, no. 5, 2013, XP055599614
BUKCZYNSKI, J ET AL.: "Costimulatory ligand 4-1BBL( CD 137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses", vol. 101, no. 5, 2004, pages 1291 - 1296, XP055125520
ANDOH, T ET AL.: "Granzyme A and proteinase-activated receptor 2 are involved in the induction of itch associated responses to mosquito allergy in mice", ACTA DERM VENEREOL, vol. 91, 2011, pages 611 - 639, XP055599620
GHERARDI ET AL., BRAIN, vol. 124, 2001, pages 1821 - 1831
GERSHENFELD ET AL., SCIENCE, vol. 232, no. 4752, 1996, pages 854 - 858
MARTINVALET ET AL., CELL, vol. 133, no. 4, 2008, pages 681 - 692
PEARSON; LIPMAN, PNAS, vol. 85, 1988, pages 2444 - 2448
IYODA ET AL., J. EXP. MED., vol. 195, no. 10, pages 1289 - 1302
FUJII S. ET AL., JOURNAL OF EXPERIMENTAL MEDICINE, vol. 198, no. 2, 2003, pages 267 - 279
See also references of EP 3466444A4
HAYES, M P ET AL.: "Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A", J EXP MED, vol. 170, no. 3, 1989, pages 933 - 946, XP000653476, DOI: doi:10.1084/jem.170.3.933
POWELL, T J ET AL.: "Examination of influenza specific T cell responses after influenza virus challenge in individuals vaccinated with MVA-NP+M1 vaccine", PLOS ONE, vol. 8, no. 5, 2013, XP055599614
BUKCZYNSKI, J ET AL.: "Costimulatory ligand 4-1BBL( CD 137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses", vol. 101, no. 5, 2004, pages 1291 - 1296, XP055125520
ANDOH, T ET AL.: "Granzyme A and proteinase-activated receptor 2 are involved in the induction of itch associated responses to mosquito allergy in mice", ACTA DERM VENEREOL, vol. 91, 2011, pages 611 - 639, XP055599620
GHERARDI ET AL., BRAIN, vol. 124, 2001, pages 1821 - 1831
GERSHENFELD ET AL., SCIENCE, vol. 232, no. 4752, 1996, pages 854 - 858
MARTINVALET ET AL., CELL, vol. 133, no. 4, 2008, pages 681 - 692
PEARSON; LIPMAN, PNAS, vol. 85, 1988, pages 2444 - 2448
IYODA ET AL., J. EXP. MED., vol. 195, no. 10, pages 1289 - 1302
FUJII S. ET AL., JOURNAL OF EXPERIMENTAL MEDICINE, vol. 198, no. 2, 2003, pages 267 - 279
See also references of EP 3466444A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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