Title:
ADJUVANT AND VACCINE COMPOSITION COMPRISING STING AGONIST
Document Type and Number:
WIPO Patent Application WO/2020/059895
Kind Code:
A1
Abstract:
The present invention relates to an adjuvant composition and a vaccine composition, each comprising a STING agonist. The adjuvant composition and the vaccine composition according to the present invention, which each comprise a STING agonist, are identified not only to have the ability to effectively activate various immune responses within the body, but also to exhibit the effect of significantly reducing the infection caused by causative agents of tuberculosis. Thus, when used in combination of vaccines against other pathogens, the compositions are expected to effectively reduce infection caused by various pathogens as well as causative agents of tuberculosis by remarkably augmenting effects of the conventional vaccines for preventing infection.
Inventors:
SHIN SUNG JAE (KR)
OH MYUNG RYURL (KR)
OH MYUNG RYURL (KR)
Application Number:
PCT/KR2018/010898
Publication Date:
March 26, 2020
Filing Date:
September 17, 2018
Export Citation:
Assignee:
QURATIS INC (KR)
International Classes:
A61K39/39; A61K39/00; A61K39/04; A61P31/06
Domestic Patent References:
| WO2016079899A1 | 2016-05-26 |
Foreign References:
| US20120039994A1 | 2012-02-16 | |||
| KR20180106825A | 2018-10-01 |
Other References:
KWON, B. E. ET AL.: "Development of new preventive and therapeutic vaccines for tuberculosis", IMMUNE NETS, vol. 18, no. 2, April 2018 (2018-04-01), pages 1 - 19, XP055651723, DOI: 10.4110/in.2018.18.e17
MCKEE, A. S. ET AL.: "Old and new adjuvant", CURR. OPIN. IMMUNOL., vol. 47, August 2017 (2017-08-01), pages 44 - 51, XP085237354
TEMIZOZ, B. ET AL.: "TLR9 and STING agonists synergistically induce innate and adaptive type-I IFN", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 45, no. 1, 2015, pages 159 - 1 169, XP055326870
MCKEE, A. S. ET AL.: "Old and new adjuvant", CURR. OPIN. IMMUNOL., vol. 47, August 2017 (2017-08-01), pages 44 - 51, XP085237354
TEMIZOZ, B. ET AL.: "TLR9 and STING agonists synergistically induce innate and adaptive type-I IFN", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 45, no. 1, 2015, pages 159 - 1 169, XP055326870
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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