Title:
ADMINISTRATION OF AN ALPHA-2 ADRENERGIC RECEPTOR AGONIST TO ENHANCE CARDIOPULMONARY RESUSCITATION
Document Type and Number:
WIPO Patent Application WO2001039761
Kind Code:
B1
Abstract:
Methods, formulations and kits are described for resuscitating a patient suffering from cardiac arrest, for enhancing the efficacy of cardiopulmonary resuscitation, for treating post-resuscitation hypotension, and for reducing the incidence of ventricular arrhythmias and myocardial dysfunction in a patient following cardiopulmonary resuscitation. Prior methods and agents often cause inotropic or chronotropic effects, which can lead to undesirable post-resuscitation myocardial dysfunction. The invention comprises administering a therapeutically effective amount of an alpha 2-receptor agonist that does not cross the blood-brain barrier, such as alpha -methylnorepinephrine, to enhance cardiopulmonary resuscitation.
Inventors:
WEIL MAX HARRY
TANG WANCHUN
BISERA JOSE
TANG WANCHUN
BISERA JOSE
Application Number:
PCT/US2000/032669
Publication Date:
November 15, 2001
Filing Date:
November 30, 2000
Export Citation:
Assignee:
INST CRITICAL CARE MEDICINE (US)
International Classes:
A61K31/00; A61K31/137; A61K45/06; (IPC1-7): A61K31/00
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