Title:
AFFIBODY MICELLE DRUG CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2024/034685
Kind Code:
A1
Abstract:
The present invention provides a novel copolymer usable in drug delivery technology. The present invention relates to a drug conjugate in which a target-specific molecule is bound to a copolymer X comprising structural units represented by the following formulae (A), (B) and (C). [In the formulae, R1, R2 and R3 are the same or different and each represent a hydrogen atom or a C1-3 alkyl group; R4 represents a C1-3 alkyl group; R5 represents a hydrogen atom, a C1-18 alkyl group, an optionally substituted 3- to 8-membered cycloalkyl group, an adamantyl group, an optionally substituted C6-18 aryl group or an optionally substituted 5- to 10-membered heteroaryl group; X1, X2 and X3 are the same or different and each represent an oxygen atom, a sulfur atom or N-R7; R6 represents a hydrogen atom, a leaving group or a linker; R7 represents a hydrogen atom or a C1-3 alkyl group; m is an integer of 1-100; and n is an integer of 0-3.]
Inventors:
SUZUKI KENICHI (JP)
YOSHIDA HIDEO (JP)
FUJIMAKI NOBUHIRO (JP)
YOSHIDA HIDEO (JP)
FUJIMAKI NOBUHIRO (JP)
Application Number:
PCT/JP2023/029357
Publication Date:
February 15, 2024
Filing Date:
August 10, 2023
Export Citation:
Assignee:
KOWA CO (JP)
International Classes:
C08F220/10; A61K31/537; A61K39/395; A61K45/00; A61K47/58; A61K47/64; A61P35/00; C08F220/30
Domestic Patent References:
| WO2008035785A1 | 2008-03-27 | |||
| WO2022168967A1 | 2022-08-11 |
Foreign References:
| US20170233714A1 | 2017-08-17 | |||
| JP2012108460A | 2012-06-07 | |||
| JP2016122174A | 2016-07-07 | |||
| JP2017105722A | 2017-06-15 |
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
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