Title:
PREVENTIVE/THERAPEUTIC AGENT FOR ALZHEIMER'S DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2007/064010
Kind Code:
A1
Abstract:
It is intended to provide a preventive/therapeutic agent for Alzheimer's dementia, characterized in that a ω-3 polyunsaturated fatty acid and thyroid hormone are used in combination. The preventive/therapeutic agent can be an alternative to a therapeutic method currently performed for Alzheimer's dementia or can achieve a high therapeutic effect by using the therapeutic method in combination and is excellent in safety.
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Inventors:
HASHIZUME KIYOSHI (JP)
Application Number:
PCT/JP2006/324172
Publication Date:
June 07, 2007
Filing Date:
December 04, 2006
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
HASHIZUME KIYOSHI (JP)
HASHIZUME KIYOSHI (JP)
International Classes:
A61K31/202; A61K31/232; A61K38/23; A61P25/28; A61P43/00
Foreign References:
| JPH0358926A | 1991-03-14 | |||
| JPH06237734A | 1994-08-30 | |||
| JPH08231391A | 1996-09-10 |
Other References:
NAKANISHI T. ET AL.: "Consideration on serum triiodothyronine (T3), thyroxine (T4) concentration and T3/T4 ratio in the patients of senile dementia", IGAKU KENKYU, vol. 60, no. 1, 1990, pages 18 - 25, XP003014021
BELANDIA B. ET AL.: "Thyroid hormone negatively regulates the transcriptional activity of the beta-amyloid precursor protein gene", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 46, 1998, pages 30366 - 30371, XP003014022
See also references of EP 1955698A4
DEMENTIA JAPAN, vol. 15, 2001, pages 21 - 29
BELANDIA B. ET AL.: "Thyroid hormone negatively regulates the transcriptional activity of the beta-amyloid precursor protein gene", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 46, 1998, pages 30366 - 30371, XP003014022
See also references of EP 1955698A4
DEMENTIA JAPAN, vol. 15, 2001, pages 21 - 29
Attorney, Agent or Firm:
WATANABE, Mochitoshi et al. (12-5 Iwamoto-cho 2-chom, Chiyoda-ku Tokyo 32, JP)
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