Title:
AGENT AND COMPOSITION FOR IMPROVING INTRAUTERINE BACTERIAL FLORA, AND METHOD FOR DETERMINING WHETHER INTRAUTERINE BACTERIAL FLORA HAS BEEN IMPROVED OR NORMALIZED
Document Type and Number:
WIPO Patent Application WO/2020/059600
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an agent for improving intrauterine bacterial flora, and a method for determining whether intrauterine bacterial flora has been improved or normalized. An aspect of the present invention is an agent for improving intrauterine bacterial flora that contains lactoferrin or a salt thereof as an active ingredient. Additionally provided are: an agent or composition for improving intrauterine flora or treating or preventing diseases caused by the imbalance of intrauterine bacterial flora, the agent or composition containing lactoferrin or a salt thereof; a method for treating or preventing diseases caused by imbalance of intrauterine bacterial flora, the method comprising administrating the agent or composition; and a method for determining whether intrauterine bacterial flora has been improved or normalized.
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Inventors:
HOSHINO TATSUO
SAKURABA YOSHIYUKI
NAGAI YOKO
KYONO KOICHI
HASHIMOTO TOMOKO
SAKURABA YOSHIYUKI
NAGAI YOKO
KYONO KOICHI
HASHIMOTO TOMOKO
Application Number:
PCT/JP2019/035731
Publication Date:
March 26, 2020
Filing Date:
September 11, 2019
Export Citation:
Assignee:
NRL PHARMA INC (JP)
VARINOS INC (JP)
VARINOS INC (JP)
International Classes:
A61K38/16; A61P15/00; A61P15/06; A61P15/08; C12N15/11; C12Q1/6851; G01N33/53; G01N33/569
Foreign References:
| JPH03109400A | 1991-05-09 | |||
| JP2018176473A | 2018-11-15 |
Other References:
OTSUKI K. ET AL.: "Potential of Lactoferrin in the Prevention of Preterm Delivery", TAIWAN ESE JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 44, no. 2, 2005, pages 123 - 127, XP026304766, DOI: 10.1016/S1028-4559(09)60123-6
KATSUFUMI OTSUKI: "Super premature birth preventive likelihood by Lactoferrin", JOURNAL OF JAPAN SOCIETY OF PERINATAL AND NEONATAL MEDICINE, vol. 40, no. 4, 30 November 2003 (2003-11-30), JP, pages 759 - 762, XP009526791, ISSN: 1348-964X
MILK SCIENCE, vol. 53, no. 4, 2004, pages 304 - 305, XP055694567, Retrieved from the Internet
HASEGAWA A. ET AL.: "Preventive effect of recombinant human lactoferrin in a rabbit preterm delivery model", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 192, no. 4, 2005, pages 1038 - 1043, XP004835937, DOI: 10.1016/j.ajog.2005.01.013
GIUNTA G. ET AL.: "Influence of lactoferrin in preventing preterm delivery: a pilot study", MOLECULAR MEDICINE REPORTS, vol. 5, no. 1, 2012, pages 162 - 166, XP055056961, DOI: 10.3892/mmr.2011.584
KYONO K. ET AL.: "Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study", REPRODUCTIVE MEDICINE AND BIOLOGY, vol. 17, no. 3, 6 May 2018 (2018-05-06), pages 297 - 306, XP055694571
MORENO I. ET AL.: "Evidence that the endometrial microbiota has an effect on implantation success or failure", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 215, no. 6, 2016, pages 684 - 703, XP055694573
BAKER JM ET AL.: "Uterine Microbiota: Residents, Tourists, or invaders?", FRONT IMMUNOL., vol. 9, 2 March 2018 (2018-03-02), pages 208
FRANASIAK JM ET AL., J ASSIST REPROD GENET, vol. 33, no. 1, January 2016 (2016-01-01), pages 129 - 36
MITCHELL CM ET AL.: "Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women", AM J OBSTET GYNECOL, vol. 212, no. 5, May 2015 (2015-05-01), pages 611
MORENO I ET AL.: "Evidence that the endometrial microbiota has an effect on implantation success or failure", AM J OBSTET GYNECOL, vol. 215, no. 6, December 2016 (2016-12-01), pages 684 - 703, XP055694573, DOI: 10.1016/j.ajog.2016.09.075
CHEN C ET AL.: "The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases", NAT COMMUN, vol. 8, no. 1, 17 October 2017 (2017-10-17), pages 875
KYONO K ET AL.: "Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study", REPROD MED BIOL, vol. 17, no. 3, pages 297 - 306, XP055694571, DOI: 10.1002/rmb2.12105
VALENTI P ET AL.: "Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense", FRONT IMMUNOL, vol. 9, 2018, pages 376
GIUNTA G ET AL.: "Influence of lactoferrin in preventing preterm delivery: a pilot study", MOL MED REP, vol. 5, no. 1, January 2012 (2012-01-01), pages 162 - 6, XP055056961, DOI: 10.3892/mmr.2011.584
OTSUKI ET AL.: "Administration of oral and vaginal prebiotic lactoferrin for a woman with a refractory vaginitis recurring preterm delivery: appearance of lactobacillus in vaginal flora followed by term delivery", J OBSTET GYNAECOL RES, vol. 40, no. 2, February 2014 (2014-02-01), pages 583 - 5
OTSUKI ET AL.: "Effects of lactoferrin in 6 patients with refractory bacterial vaginosis", BIOCHEM CELL BIOL, vol. 95, no. 1, February 2017 (2017-02-01), pages 31 - 33
PINO A ET AL.: "Bacterial biota of women with bacterial vaginosis treated with lactoferrin: an open prospective randomized trial", MICROB ECOL HEALTH DIS, vol. 28, no. 1, 2017, pages 1357417
WALTERS, W. ET AL.: "Improved bacterial 16S rRNA gene (V4 and V4-5) and fungal internal transcribed spacer marker gene primers for microbial community surveys", MSYSTEMS, vol. 1, no. 1, 2016, pages e00009 - 15
See also references of EP 3854412A4
KATSUFUMI OTSUKI: "Super premature birth preventive likelihood by Lactoferrin", JOURNAL OF JAPAN SOCIETY OF PERINATAL AND NEONATAL MEDICINE, vol. 40, no. 4, 30 November 2003 (2003-11-30), JP, pages 759 - 762, XP009526791, ISSN: 1348-964X
MILK SCIENCE, vol. 53, no. 4, 2004, pages 304 - 305, XP055694567, Retrieved from the Internet
HASEGAWA A. ET AL.: "Preventive effect of recombinant human lactoferrin in a rabbit preterm delivery model", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 192, no. 4, 2005, pages 1038 - 1043, XP004835937, DOI: 10.1016/j.ajog.2005.01.013
GIUNTA G. ET AL.: "Influence of lactoferrin in preventing preterm delivery: a pilot study", MOLECULAR MEDICINE REPORTS, vol. 5, no. 1, 2012, pages 162 - 166, XP055056961, DOI: 10.3892/mmr.2011.584
KYONO K. ET AL.: "Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study", REPRODUCTIVE MEDICINE AND BIOLOGY, vol. 17, no. 3, 6 May 2018 (2018-05-06), pages 297 - 306, XP055694571
MORENO I. ET AL.: "Evidence that the endometrial microbiota has an effect on implantation success or failure", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 215, no. 6, 2016, pages 684 - 703, XP055694573
BAKER JM ET AL.: "Uterine Microbiota: Residents, Tourists, or invaders?", FRONT IMMUNOL., vol. 9, 2 March 2018 (2018-03-02), pages 208
FRANASIAK JM ET AL., J ASSIST REPROD GENET, vol. 33, no. 1, January 2016 (2016-01-01), pages 129 - 36
MITCHELL CM ET AL.: "Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women", AM J OBSTET GYNECOL, vol. 212, no. 5, May 2015 (2015-05-01), pages 611
MORENO I ET AL.: "Evidence that the endometrial microbiota has an effect on implantation success or failure", AM J OBSTET GYNECOL, vol. 215, no. 6, December 2016 (2016-12-01), pages 684 - 703, XP055694573, DOI: 10.1016/j.ajog.2016.09.075
CHEN C ET AL.: "The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases", NAT COMMUN, vol. 8, no. 1, 17 October 2017 (2017-10-17), pages 875
KYONO K ET AL.: "Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study", REPROD MED BIOL, vol. 17, no. 3, pages 297 - 306, XP055694571, DOI: 10.1002/rmb2.12105
VALENTI P ET AL.: "Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense", FRONT IMMUNOL, vol. 9, 2018, pages 376
GIUNTA G ET AL.: "Influence of lactoferrin in preventing preterm delivery: a pilot study", MOL MED REP, vol. 5, no. 1, January 2012 (2012-01-01), pages 162 - 6, XP055056961, DOI: 10.3892/mmr.2011.584
OTSUKI ET AL.: "Administration of oral and vaginal prebiotic lactoferrin for a woman with a refractory vaginitis recurring preterm delivery: appearance of lactobacillus in vaginal flora followed by term delivery", J OBSTET GYNAECOL RES, vol. 40, no. 2, February 2014 (2014-02-01), pages 583 - 5
OTSUKI ET AL.: "Effects of lactoferrin in 6 patients with refractory bacterial vaginosis", BIOCHEM CELL BIOL, vol. 95, no. 1, February 2017 (2017-02-01), pages 31 - 33
PINO A ET AL.: "Bacterial biota of women with bacterial vaginosis treated with lactoferrin: an open prospective randomized trial", MICROB ECOL HEALTH DIS, vol. 28, no. 1, 2017, pages 1357417
WALTERS, W. ET AL.: "Improved bacterial 16S rRNA gene (V4 and V4-5) and fungal internal transcribed spacer marker gene primers for microbial community surveys", MSYSTEMS, vol. 1, no. 1, 2016, pages e00009 - 15
See also references of EP 3854412A4
Attorney, Agent or Firm:
MAE Naomi (JP)
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