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Title:
AGENT AND COMPOSITION FOR INDUCING EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR
Document Type and Number:
WIPO Patent Application WO/2017/104706
Kind Code:
A1
Abstract:
[Problem] To provide a drug or composition in which the active ingredient is an herbal medicine or extract having BDNF gene expression-inducing activity. [Solution] Licorice, amomum seed, polygonum root, astragalus root, kudzu root, Japanese pepper, red peony root , rhubarb, uncaria hook, sophora, dried aconite tuber, ephedra, Chinese moonseed, and lesser galangal, and extracts thereof, have BDNF gene expression-inducing activity, and a traditional Chinese medicine that uses these herbs alone, mixtures thereof, or these herbs in combination with other herbs is useful in improving the cerebral dysfunction associated with psychiatric disorders and neurodegenerative diseases such as depression and Alzheimer's disease.

Inventors:
TSUDA MASAAKI (JP)
FUKUCHI MAMORU (JP)
MORI HISASHI (JP)
Application Number:
PCT/JP2016/087237
Publication Date:
June 22, 2017
Filing Date:
December 14, 2016
Export Citation:
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Assignee:
NAT UNIV CORP UNIV OF TOYAMA (JP)
International Classes:
A61K36/17; A61K36/258; A61K36/481; A61K36/484; A61K36/488; A61K36/489; A61K36/59; A61K36/65; A61K36/704; A61K36/708; A61K36/714; A61K36/74; A61K36/758; A61K36/9062; A61K36/9064; A61P25/28
Foreign References:
JP2011504884A2011-02-17
JPH0725777A1995-01-27
Other References:
PATIL,SANGITA P. ET AL.: "Glycyrrhiza uralensis flavonoids inhibit brain microglial cell TNF-alpha secretion,p-IKB expression,and increase brain- derived neurotropic factor(BDNF) secretion", JOURNAL OF TRADITIONAL CHINESE MEDICAL SCIENCES, vol. 1, no. 1, 2014, pages 28 - 37, XP055391525, ISSN: 2095-7548
TADAYOSHI UESATO: "Screening of natural medicines that promote neurites outgrowth by C2C12 cell -cultured medium", MEDICINE AND BIOLOGY, vol. 155, no. 9, 2011, pages 602 - 606, ISSN: 0019-1604
LIU JUAN ET AL.: "Ginsenoside Rb1 regulates the expressions of brain-derived neurotrophic factor and caspase-3 and induces neurogenesis in rats with experimental cerebral ischemia", JOURNAL OF ETHNOPHARMACOLOGY, vol. 132, no. 2, 2010, pages 393 - 399, XP027452987, ISSN: 0378-8741
KIM MIA ET AL.: "Effects of ginsenoside Rb1 on the stress-induced changes of BDNF and HSP70 expression in rat hippocampus", ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, vol. 38, no. 1, 2014, pages 257 - 262, XP055391527, ISSN: 1382-6689
KIM,DONG-HOON ET AL.: "Effects of Korea red ginseng total saponin on repeated unpredictable stress-induced changes in proliferation on neural progenitor cells and BDNF mRNA expression in adult rat hippocampus", JOURNAL OF GINSENG RESEARCH, vol. 28, no. 2, 2004, pages 94 - 103, XP053008215, ISSN: 1226-8453
JIANG,BO ET AL.: "Antidepressant -like effects of ginsenoside Rgl are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus", BRITISH JOURNAL OF PHARMACOLOGY, vol. 166, no. 6, 2012, pages 1872 - 1887, XP055391528, ISSN: 1476-5381
Attorney, Agent or Firm:
OTANI Kaichi (JP)
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