Title:
AGENT COMPRISING IMIDAZOLE DIPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2015/146522
Kind Code:
A1
Abstract:
Provided is a natural-derived antiaging agent. The antiaging agent comprises as an active ingredient at least one member selected from the group consisting of imidazole dipeptides and metabolites thereof. Also provided is an agent for improving neuropsychological functions, said agent comprising as an active ingredient at least one member selected from the group consisting of imidazole dipeptides and metabolites thereof. Also provided are: an agent for changing the expression of a transporter such as SLC23A2, said agent comprising at least one member selected from the group consisting of imidazole dipeptides and metabolites thereof; an agent for regulating the concentration of a cytokine such as IP-10 in blood, said agent comprising at least one member selected from the group consisting of imidazole dipeptides and metabolites thereof; a method for detecting an improvement or worsening in neuropsychological functions; and a kit for detecting an improvement or worsening in neuropsychological functions.
Inventors:
HISATSUNE TATSUHIRO (JP)
TOTSUKA MAMORU (JP)
SATSU HIDEO (JP)
KANEKO JUN (JP)
KATAKURA YOSHINORI (JP)
SATO MIKAKO (JP)
MATSUMOTO TAKASHI (JP)
MORIMATSU FUMIKI (JP)
IMABAYASHI ETSUKO (JP)
MATSUDA HIROSHI (JP)
TOTSUKA MAMORU (JP)
SATSU HIDEO (JP)
KANEKO JUN (JP)
KATAKURA YOSHINORI (JP)
SATO MIKAKO (JP)
MATSUMOTO TAKASHI (JP)
MORIMATSU FUMIKI (JP)
IMABAYASHI ETSUKO (JP)
MATSUDA HIROSHI (JP)
Application Number:
PCT/JP2015/056412
Publication Date:
October 01, 2015
Filing Date:
March 04, 2015
Export Citation:
Assignee:
UNIV TOKYO (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
NH FOODS LTD (JP)
NAT CT NEUROLOGY & PSYCHIATRY (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
NH FOODS LTD (JP)
NAT CT NEUROLOGY & PSYCHIATRY (JP)
International Classes:
A61K38/00; A61P3/10; A61P25/28; A61P29/00; A61P43/00
Domestic Patent References:
| WO2003013514A1 | 2003-02-20 | |||
| WO2007116987A1 | 2007-10-18 |
Other References:
BRUNO HERCULANO ET AL.: "beta-Alanyl-L-Histidine Rescues Cognitive Deficits Caused by Feeding a High Fat Diet in a Transgenic Mouse Model of Alzheimer's Disease", JOURNAL OF ALZHEIMER'S DISEASE, vol. 33, no. 4, 2013, pages 983 - 997, XP055358545
CARLO CORONA ET AL.: "Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice", PLOS ONE, vol. 6, no. 3, March 2011 (2011-03-01), pages 1 - 8, XP055225492
JAMES N.BARANIUK ET AL.: "Carnosine Treatment for Gulf War Illness: A Randomized Controlled Trial", GLOBAL JOURNAL OF HEALTH SCIENCE, vol. 5, no. 3, 2013, pages 69 - 81, XP055225493
ALESSANDRA ALOISI ET AL.: "Anti-Aggregating Effect of the Naturally Occurring Dipeptide Carnosine on Abeta1-42 Fibril Formation", PLOS ONE, vol. 8, no. 7, July 2013 (2013-07-01), pages 1 - 12, XP055368672
See also references of EP 3124034A4
CARLO CORONA ET AL.: "Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice", PLOS ONE, vol. 6, no. 3, March 2011 (2011-03-01), pages 1 - 8, XP055225492
JAMES N.BARANIUK ET AL.: "Carnosine Treatment for Gulf War Illness: A Randomized Controlled Trial", GLOBAL JOURNAL OF HEALTH SCIENCE, vol. 5, no. 3, 2013, pages 69 - 81, XP055225493
ALESSANDRA ALOISI ET AL.: "Anti-Aggregating Effect of the Naturally Occurring Dipeptide Carnosine on Abeta1-42 Fibril Formation", PLOS ONE, vol. 8, no. 7, July 2013 (2013-07-01), pages 1 - 12, XP055368672
See also references of EP 3124034A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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