Title:
AGENT COMPRISING MESENCHYMAL STEM CELL OR AGRP FOR TREATMENT OF DEGENERATIVE BRAIN DISEASE THROUGH INCREASE IN UBIQUITIN PROTEASOME ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2018/052182
Kind Code:
A1
Abstract:
A composition comprising mesenchymal stem cells, or AgRP or an active fragment thereof according to one aspect has the effect of being useful for preventing, treating, or alleviating a disease associated with decrease activity of ubiquitin proteasome, for example, a degenerative brain disease by increasing the activity of ubiquitin proteasome.
Inventors:
CHANG JONG WOOK (KR)
NA DUK L (KR)
LEE NA KYUNG (KR)
NA DUK L (KR)
LEE NA KYUNG (KR)
Application Number:
PCT/KR2017/007174
Publication Date:
March 22, 2018
Filing Date:
July 05, 2017
Export Citation:
Assignee:
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
International Classes:
A61K35/28; A23L33/13; A23L33/18; A61K35/35; A61K35/50; A61K35/51; A61K48/00; G01N33/68
Domestic Patent References:
| WO2012136587A1 | 2012-10-11 |
Foreign References:
| US20120020936A1 | 2012-01-26 |
Other References:
LEE, P. H. ET AL.: "Bone Marrow-derived Mesenchymal Stem Cell Therapy as a Candidate Disease-modifying Strategy in Parkinson's Disease and Multiple System Atrophy", JOURNAL OF CLINICAL NEUROLOGY, vol. 5, no. 1, 2009, pages 1 - 10, XP055476198
LEE, S. T. ET AL.: "Slowed Progression in Models of Huntington Disease by Adipose Stem Cell Transplantation", ANNALS OF NEUROLOGY, vol. 66, no. 5, 2009, pages 671 - 681, XP055476200
LEE, N. K. ET AL.: "Agouti Related Peptide Secreted via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Mode l", SCIENTIFIC REPORTS, vol. 7, no. 39340, 4 January 2017 (2017-01-04), pages 1 - 9, XP055476199
LEE, S. T. ET AL.: "Slowed Progression in Models of Huntington Disease by Adipose Stem Cell Transplantation", ANNALS OF NEUROLOGY, vol. 66, no. 5, 2009, pages 671 - 681, XP055476200
LEE, N. K. ET AL.: "Agouti Related Peptide Secreted via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Mode l", SCIENTIFIC REPORTS, vol. 7, no. 39340, 4 January 2017 (2017-01-04), pages 1 - 9, XP055476199
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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