Title:
AGENT FOR IMPROVING GLUCOSE TOLERANCE DISORDER
Document Type and Number:
WIPO Patent Application WO/2015/193962
Kind Code:
A1
Abstract:
An agent for improving glucose tolerance disorder that comprises, as an active ingredient, partition chromatography peak components of an alcoholic extract of gramineous plant seeds, said peak components preferably comprising an alkyl resorcinol (AR) mixture containing multiple kinds of alkyl resorcinols. This mixture preferably contains an AR of general formula (I) wherein R1 is a saturated or unsaturated alkyl group having 15 carbon atoms, an AR of general formula (I) wherein R1 is a saturated or unsaturated alkyl group having 17 carbon atoms, an AR of general formula (I) wherein R1 is a saturated or unsaturated alkyl group having 19 carbon atoms, an AR of general formula (I) wherein R1 is a saturated or unsaturated alkyl group having 21 carbon atoms, an AR of general formula (I) wherein R1 is a saturated or unsaturated alkyl group having 23 carbon atoms, and an AR of general formula (I) wherein R1 is a saturated or unsaturated alkyl group having 25 carbon atoms, each in a specific amount.
In general formula (I): R1 represents a saturated or unsaturated alkyl group having 15-25 carbon atoms; and R2 represents a hydrogen atom or a methyl group.
Inventors:
OISHI KATSUTAKA (JP)
ITOH NANAKO (JP)
YAMAMOTO SAORI (JP)
FUKUDOME SHIN-ICHI (JP)
KIKUCHI YOSUKE (JP)
OKITA KIMIKO (JP)
ITOH NANAKO (JP)
YAMAMOTO SAORI (JP)
FUKUDOME SHIN-ICHI (JP)
KIKUCHI YOSUKE (JP)
OKITA KIMIKO (JP)
Application Number:
PCT/JP2014/066007
Publication Date:
December 23, 2015
Filing Date:
June 17, 2014
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
NISSHIN SEIFUN GROUP INC (JP)
ORIENTAL YEAST CO LTD (JP)
NISSHIN SEIFUN GROUP INC (JP)
ORIENTAL YEAST CO LTD (JP)
International Classes:
A61K36/899; A23K1/16; A23K1/18; A23L1/30; A61K31/047; A61P3/10
Foreign References:
| CN103005282A | 2013-04-03 | |||
| JP2005247695A | 2005-09-15 | |||
| JP2014139166A | 2014-07-31 | |||
| JP2004161656A | 2004-06-10 | |||
| JPH06100440A | 1994-04-12 | |||
| JP2005068132A | 2005-03-17 |
Other References:
NATALIJA, B. ET AL.: "Content of alkylresorcinols in cereals grown in Latvia determined by high performance liquid chromatography with UV", PROCEEDINGS OF THE LATVIAN ACADEMY OF SCIENCES, SECTION B, vol. 67, no. 4/5, 2013, pages 389 - 393, XP055246779, ISSN: 1407-009x
ROSS, A.B. ET AL.: "Dietary Alkylresorcinols: Absorption, Bioactivities, and Possible Use as Biomarkers of Whole-grain Wheat- and Rye-rich Foods", NUTRITION REVIEWS, vol. 62, no. 3, 2004, pages 81 - 95
JU-SUNG KIM ET AL.: "T he inhibitory effects of ethanol extracts from sorghum, foxtail millet and proso millet on alpha-glucosidase and alpha- amylase activities", FOOD CHEMISTRY, vol. 124, no. 4, 2011, pages 1647 - 1651, XP027339954, ISSN: 0308-8146
SHOBANA,S. ET AL.: "Composition and enzyme inhibitory properties of finger millet (Eleusine coracana L.) seed coat phenolics: Mode of inhibition of a-glucosidase and pancreatic amylase", FOOD CHEMISTRY, vol. 115, no. 4, 2009, pages 1268 - 1273, XP026077368, ISSN: 0308-8146
ROSS, A.B. ET AL.: "Dietary Alkylresorcinols: Absorption, Bioactivities, and Possible Use as Biomarkers of Whole-grain Wheat- and Rye-rich Foods", NUTRITION REVIEWS, vol. 62, no. 3, 2004, pages 81 - 95
JU-SUNG KIM ET AL.: "T he inhibitory effects of ethanol extracts from sorghum, foxtail millet and proso millet on alpha-glucosidase and alpha- amylase activities", FOOD CHEMISTRY, vol. 124, no. 4, 2011, pages 1647 - 1651, XP027339954, ISSN: 0308-8146
SHOBANA,S. ET AL.: "Composition and enzyme inhibitory properties of finger millet (Eleusine coracana L.) seed coat phenolics: Mode of inhibition of a-glucosidase and pancreatic amylase", FOOD CHEMISTRY, vol. 115, no. 4, 2009, pages 1268 - 1273, XP026077368, ISSN: 0308-8146
Attorney, Agent or Firm:
HATORI, Osamu (JP)
Osamu Hatori (JP)
Osamu Hatori (JP)
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